Pharmacology Of Anti-Obesity Drugs (BANKS) - Endocrine Exam 2

Norepinephrine; CV disease

Phentermine works by increasing ____, and has sympathetic side effects, which is why it is contraindicated in _______

Norepinephrine;GABA

Phentermine/Topiramate works with increasing_____ and _______ to reduce appetite - also sympathetic side effects

Gut-brain

GLP-1’s work on the _______ axis

Digestion; dietary fat

Orlistat blocks the _______ and absorption of _______

anorexegenic pathway (Satiety)

POMC/CART is the

orexegenic pathway (hunger)

NPY/AgRP pathway is the

prodrugs

Phendimetrazine, Diethylpropion, lisdexamfetamine are all ______ for DA/NE pathway to promote satiety

anorexegenic

The Mu receptor inhibits the ________ pathway, and naltrexone (in bupropion/naltrexone) is Mu-receptor antagonist

Orlistat

Steatorrhea, fecal incontinence, flatulence, are all symptoms of this medication

hypothalamic neurons; gastric emptying; glucagon secretion

Pramlintide is a amylin analog and decreases appetite and increases satiety via ____, and slows____, and decreases ____

MC4R

Setmelanotide works at the _______ receptor, and activates it in the absence of alpha-melanocyte stimulating hormone