Important 200 - Anti-Inflammatory

What is the brand name of methylprednisolone?

Medrol

What is the generic name of Medrol?

Methylprednisolone

What class is methylprednisolone (Medrol)?

Systemic corticosteroid

What is the mechanism of methylprednisolone (Medrol)?

Decreases inflammation by suppressing leukocyte migration

Is methylprednisolone (Medrol) available over-the-counter?

No

What is the indication of methylprednisolone (Medrol)?

Immunosuppressant

In which patients is methylprednisolone (Medrol) dose-adjusted?

Obesity (BMI ≥ 30, use IBW)

In what dosage forms is methylprednisolone (Medrol) available?

- Solution for injection

- Suspension for injection

- Oral tablet

What are the monitoring parameters for methylprednisolone (Medrol)?

- Bone density

- Blood pressure

- Blood sugar

- Electrolytes

- Eyes

- Growth and development in children

- Weight

What are the endocrine and metabolic adverse reactions of methylprednisolone (Medrol)?

- Glucose intolerance/hyperglycemia

- Delayed growth in children

What are the contraindications to (oral) methylprednisolone (Medrol)?

- Diabetes

- Hypertension

- Glaucoma

- Systemic fungal infection

- Active tuberculosis

What are the drug interactions for methylprednisolone (Medrol)?

- Blood thinners

- NSAIDs

- Diabetes medications

- Seizure medications

- Live vaccines

- Grapefruit juice

- Alcohol

What are the gastrointestinal adverse reactions of methylprednisolone (Medrol)?

- Increased appetite

- Increased gastric acid production

What are the cardiovascular adverse reactions of methylprednisolone (Medrol)?

- Hypertension

- Edema

What are the ocular adverse reactions of methylprednisolone (Medrol)?

- Cataracts

- Glaucoma

What are the CNS adverse reactions of methylprednisolone (Medrol)?

- Insomnia

- Nervousness

- Psychosis (high doses)

What is the dermatologic adverse reaction of methylprednisolone (Medrol)?

Hirsutism

What are the two systemic adverse reactions of methylprednisolone (Medrol)?

- Iatrogenic Cushing syndrome

- Steroid-induced osteoporosis

What are the patient counseling points for methylprednisolone (Medrol)?

- Never discontinue without contacting provider

- Take with food if GI upset occurs

- Wear a medical alert bracelet if on chronic therapy

What is prednisone?

Systemic corticosteroid

What is the mechanism of prednisone?

Decreases inflammation by suppressing leukocyte migration

Is prednisone available over-the-counter?

No

What is the indication of prednisone?

Immunosuppressant

In which patients is prednisone dose-adjusted?

- Severe liver dysfunction

- Obesity (BMI ≥ 30, use IBW)

In what dosage forms is prednisone available?

- Oral solution

- Oral tablet

- Oral concentrate

- Oral delayed-release tablet

What are the monitoring parameters for prednisone?

- Bone density

- Blood pressure

- Blood sugar

- Electrolytes

- Eyes

- Growth and development in children

- Weight

What are the endocrine and metabolic adverse reactions of prednisone?

- Glucose intolerance/hyperglycemia

- Delayed growth in children

What are the gastrointestinal adverse reactions of prednisone?

- Increased appetite

- Increased gastric acid production

What are the cardiovascular adverse reactions of prednisone?

- Hypertension

- Edema

What are the ocular adverse reactions of prednisone?

- Cataracts

- Glaucoma

What are the CNS adverse reactions of prednisone?

- Insomnia

- Nervousness

- Psychosis (high doses)

What is the dermatologic adverse reaction of prednisone?

Hirsutism

What are the two systemic adverse reactions of prednisone?

- Iatrogenic Cushing syndrome

- Steroid-induced osteoporosis

What are the patient counseling points for prednisone?

- Never discontinue without contacting provider

- Take with food if GI upset occurs

- Wear a medical alert bracelet if on chronic therapy

What are the drug interactions of prednisone?

- Blood thinners

- NSAIDs

- Diabetes medications

- Seizure medications

- Live vaccines

- Grapefruit juice

- Alcohol

What are the contraindications to prednisone?

- Diabetes

- Hypertension

- Glaucoma

- Systemic fungal infection

- Active tuberculosis