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urinary system function
rids body of waste products
kidneys play an important role in blood
volume, pressure, and composition
the urinary system is closely associated with most other body systems, particularly the
cardiovascular system
components of urinary system
kidneys, ureters, bladder, urethra
hilum
spot on kidneys where arteries and veins enter and exit
kidneys sit
behind abdominal cavity in dual membrane sac
compared to the left kidney, the right kidney is
lower and smaller
levels of kidney protection from external to internal
perirenal fat, renal fascia, pararenal fat
papilla in kidney direct urine to
retention cups
major and minor calyces function to
collect urine
kidneys receive WP of cardiac output?
21%
nephrons are primarily in
cortex, but there are some in the medulla also
corpuscle
big ball with hollowed out space for network of afferent arteriole that is tangled up
afferent vessel
goes in
efferent vessel
goes out
space around glomerulus is called
capsular space (contains water)
filtrate production
blood flows into glomerulus, both water and solutes are filtered from blood plasma, and what is left is called filtrate
tubular fluid changes and flow
blood plasma is now called filtrate as it enters proximal convoluted tubule. it flows through the PCT, nephron loop, distal convoluted tubule, collecting tubules, and then collecting ducts, and now it is urine
blood flows in kidney,
cortex, and then corpuscle, and then the tube system
180 L of filtrate
are formed daily
filtrate composition
filtered plasma with solutes and little protein
once filtrate is caught in capsular space, it is then funneled into the
proximal convoluted tubule
the visceral layer of glomerular capsule has holes called filtration slits so that
small molecules can pass through while large proteins cannot
blood pressure needs to be high enough to
push stuff out of the filtration slits
osmotic pressure comes from
large proteins that are too big to fit through the filtration slits
glomerular filtration rate
filtrate formed per minute by kidneys
the filtrate formed per day is about 50-60x
the amount of blood in your body
kidneys use GFR to determine
health, especially cardiovascular health
kidneys will sacrifice GFR in order to
maintain blood pressure
intrinsic mechanisms are within the kidneys, while
extrinsic mechanisms are outside of the kidneys
myogenic response
intrinsic response to maintain GFR
myogenic response steps
when blood pressure increases, the renal corpuscle flow goes u, and pushes on afferent vessel walls, creating stretch, which stimulates granular cells to constrict, to slow blood flow to maintain GFR
juxtaglomerular apparatus
a collection of cells at the vascular pole
vascular pole
intersection of afferent and efferent arterioles and convoluted tubule
juxtaglomerular apparatus
a monitoring system that consists of macula densa cells and granular cells
when blood flow is too high,
macula densa cells will sense the extra sodium that should’ve been filtered out, and will tell granular cells to constrict to maintain GFR
intrinsic responses do NOT
rely on nervous system or hormones
myogenic response reacts to blood pressure changes, while the tubuloglomerular response reacts to
NaCl levels in filtrate (both adjust diameter of afferent arteriole)
when blood pressure increases, urine levels will
increase, and VV
kidneys can help restore
good BP
which systems/organs feed into kidneys to maintain BP?
nervous system, liver, and heart
GI tract
30 ft continuous tube lined with a mucus membrane
accessory organs
salivary glands, liver, pancreas, and spleen
liver has ducts
that secrete solutions into intestine
pancreas secretes juices that
aid in digestion
spleen function
breakdown and filtering during digestion
functions of GI tract
ingestion, motility, secretions, digestion, absorption, and elimination
peritoneal cavity
space between the double-layered cavity that surrounds organs
mesentery
a fold of tissue that is a route for blood vessels, lymphatics, and nerves. and holds organs in place and stores fat
lumen
the opening in the GI tract that food goes through
tunics of GI tract
mucosa, submucosa, muscularis, and serosa
submucosa layer has
blood vessels and submucosal nerve plexus
muscularis layer
propels food and has nerve plexus
mucosa layer function
absorption
serosa layer
CT outermost layer that provides structural support
2 types of propulsion
peristalsis (adjacent segments, one direction flow) and segmentation (nonadjacent segments, back and forth flow to mix)
buccal cavity (vestibule)
between gums, lips, and cheek
oral cavity proper
central to buccal cavity, hard palate and tongue area
hard palate is composed of
palatine bones and palatine process of maxillae (slightly corrugated)
intrinsic salivary glands
continuous secretions independent of food. breaks down triglycerides
soft palate
skeletal muscle that closes off nasopharynx
extrinsic glands are
parotid, submandibular, and sublingual
parotid gland
anterior to ear, and secretes 20-30% of saliva
submandibular gland
floor of mandible. secretes 60-70% of saliva and releases under tongue
sublingual gland
under tongue. secretes3-5% of saliva
serous cells secrete saliva while
mucous cells secrete mucus
parotid and submandibular glands are mostly serous while the
sublingual gland is mostly mucous
secretions are
97-99.5% water, with electrolytes, salivary amylase, lingual lipase (intrinsic glands only), mucin, metabolic waste, etc.
mastication
mechanical digestion in oral cavity to increase surface area of food for enzyme breakdown
mastication is regulated in the
center of the brainstem
muscles involved in mastication
temporalis and masseter muscles
nasopharynx is in the
posterior wall of nasal cavity
oropharynx is in the
posterior wall of oral cavity
laryngopharynx is found
behind the larynx and connects the pharynx to the esophagus
esophagus f and l
pathway for a food bolus and is found behind the trachea, anterior to the vertebral column
esophagus 2 sphincters
inferior and superior, both push food down to stomach by peristalsis
inferior sphincter is also known as
cardia sphincter
one thing the esophagus does NOT do is
digest. it is ONLY a passing tube
deglutition 3 stages:
oral phase, pharyngeal phase, and esophageal phase
which phases of deglutition are voluntary and involuntary?
oral is voluntary (from mouth to throat) and pharyngeal (from oropharynx to esophagus) and esophageal (from esophagus to stomach) are involuntary
where is protein digestion done
in the stomach
stomach 3 layers of smooth muscle:
longitudinal, circular, and oblique (outer to inner)
during stomach digestion, cardia and pyloric sphincter are both
CLOSED
gastric folds are folds in the stomach that have
pits lined with epithelial cells that secrete mucus, acid, hormones, and enzymes, all to digest proteins
which digestive epithelial cells secrete mucin?
surface mucous cell and mucous neck cell
which digestive epithelial cell secretes pepsinogen (unactivated enzyme)
chief cell
which digestive epithelial cell secretes gastrin (to make cells secrete more juices)
G-cell
which digestive epithelial cell secretes H, Cl, and intrinsic factor?
parietal cell
when you ingest protein, chief cells are stimulated by pH change to secrete, then parietal cells
secrete HCl, which denatures protein and activates pepsinogen into pepsin
how many L of gastric juices are made a day
3 L
end product of mouth digestion
bolus
end product of stomach digestion
chyme
contents of stomach are gradually
released into duodenum
phase 1, cephalic phase is triggered by
thinking about, seeing, or smelling food. the parasympathetic center excite pepsin and acid production
phase 2, gastric phase happens in
stomach and makes chyme
phase 3, intestinal phase
shuts down stomach motion