Wound Healing - Fill-in-the-Blank Flashcards

Fill-in-the-blank flashcards covering key concepts in wound healing: cell types (labile/stable/permanent), phases (reactive, proliferative, maturation), cellular players (macrophages, neutrophils, fibroblasts, myofibroblasts), collagen dynamics, primary vs secondary intention, and systemic/local factors affecting healing.

The three categories of cells based on regenerative capacity are __, __ and __.

labile cells, stable cells, and permanent cells

Tissue Repair is the continuity of a tissue’s framework is restored through the formation of __.

scar tissue

Wound Healing is the __ of lost functional tissue after injury.

restoration

The aims of wound healing are to remove damaged tissue, fill the gap caused by tissue destruction, and __ the structural continuity of the injured part.

restore

Phase 1 of wound healing is the __ phase.

reactive

During Phase 1, local blood vessels become more permeable, allowing __ to seep into injured areas.

platelets

The surface dries to form a __.

scab

Phase 2: Repair/Proliferative Phase involves production of __ tissue and re-epithelialisation.

granulation

Granulation tissue initially appears bright red, then turns __.

pink

Collagen fibres are deposited __, then fibres become cross‑lined in an organised lattice.

haphazardly

Over-production of collagen leads to a raised/thickened __.

scar

Fibroblasts differentiate into __ in the wound to facilitate contraction.

myofibroblasts

Myofibroblasts have __ properties.

contractile

Clot separates from basement membrane and creates a bridge between the edges of the wound; clot dissolves and __ occurs.

regeneration

Epithelial layer begins to grow under clot; Keratinocytes leap frog over each other to __ the gap.

close

Phase 3 is the __/Remodelling phase.

Maturation

Scar tissue never fully regains the strength of the original __.

tissue

An example of Primary Intention is a __.

cut on the finger

Secondary Intention requires generation of larger amounts of __ tissue.

granulation

Secondary Intention leads to contraction at the edge of the wound to bring them close, resulting in a large __.

scar

Healing in Secondary Intention is __ with more complications such as contractions of the injury site.

prolonged

Infection can cause the wound edges to __ open.

split open

Poor Nutrition Supply: New tissue requires increased levels of __, proteins, vitamins and other nutrients to sustain growth.

glucose

↓ oxygen supply means new tissue has increased metabolic demands and requires higher levels of __.

oxygen

Anticancer drugs, immunosuppressants & glucocorticoids __ healing processes.

impair

Inadequate blood flow cannot sustain the supply of oxygen and __ for tissue growth.

nutrients