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Fuel metabolism in diabetes mellitus
Deficiency in insulin and increase in glucagon, other counterregulatory hormones
Hyperglycemia
T1D
T2D
Hyperglycemia
Induce acute and chronic complications
T1D
Increased mobilization of FFAAs causes increased hepatic synthesis of ketone bodies
Diabetic ketoacidosis
What is diabetic ketoacidosis
More common in those with T1D
No insulin available the cell body doesn’t get glucose and uses other sources like lipids and proteins to produce glucose which produces ketones
T2D
ketone bodies not sufficient for development of DKA, hyperosmolarity
What is hyperosmolarity
When you have to much glucose and affect the osmolarity of the body