Lecture 6: Endocytosis and Lysosomal System

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Last updated 5:04 PM on 7/23/26
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20 Terms

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Gaucher Disease

lysosomal storage disease

Mutation in beta-glucocerebrosidase → which is an enzyme responsible for breaking down lipids

excess of lipids leads to bone breakdown

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Endocytosis

An active transport process where cels absorb large molecules, fluids, or pathogens by engulfing them with their plasma membrane

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Pinocytosis

type of Endocytosis

“Cell drinking”

  • small vesicles

  • completely indiscriminate → takes in everything in fluid

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Macropinocytosis

type of Endocytosis

Larger vesicle

Get rid of Red blood cells

Indiscriminate → takes everything in fluid

<p>type of Endocytosis</p><p>Larger vesicle</p><p>Get rid of <strong>Red blood cells</strong></p><p>Indiscriminate → takes everything in fluid</p>
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Clathrin associated receptor mediated endocytosis

type of Endocytosis

Specific receptors for cargo into and within a cell

100-150nm

<p>type of Endocytosis</p><p><strong>Specific receptors for cargo </strong>into and within a cell</p><p>100-150nm</p>
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Caveolae

type of Endocytosis

Little caves → 50-80 nm

important in endothelial cells

<p>type of Endocytosis</p><p>Little caves → 50-80 nm</p><p>important in endothelial cells</p>
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Phagocytosis

type of Endocytosis

“Cell eating”

  • Large vesicles

  • Consume Microorganisms and cell debris

<p>type of Endocytosis</p><p>“Cell <strong>eating</strong>”</p><ul><li><p><strong>Large</strong> vesicles</p></li><li><p>Consume Microorganisms and cell debris</p></li></ul><p></p>
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early endosome, late endosome, lysosome

endocytosis path way

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Clathrin

Forms triskeleton structure (3 legs) → forms a closed cage

heavy chain, light chain, binding site for assembly particles

<p>Forms triskeleton structure (3 legs) → forms a closed cage</p><p>heavy chain, light chain, binding site for assembly particles</p>
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1000 fold concentration of clathrinCholesterol, vitamine b12, iron, viruses - influenzA, SARS-cov

1000 fold concentration of clathrin

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golgi apparatus, lysosome

what is the origin and destination of Clathrin + adaptin 1

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plasma membrane, endosomes

what is the origin and destination of Clathrin + adaptin 2

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ER, Golgi cisterna, Golgi apparatus

what is the origin and destination of COP proteins?

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Transferrin (Tfn)

Does not disassociate from its receptor

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LDL

This cargo dissassociates quickets (in endosome) from receptor at pH 6.5

it’s receptor goes back to plasma membrane

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Iron

Dissociates quickly rom transferring (pH 6) → recycles back to plasma membrane

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MPR

In late endosome, it dissociates from the receptors and receptor travels back to goligi to pick up _____ proteins

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EGF

stays bound to its receptor and gets transferred in lysosome; receptor and _____ both get degraded in the lysosome

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M6P

protects lysosomal enzymes from being broken down

synthesized in golgi

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envelopment, sealing, merging with lysosome, residual body

Stages of autophagy