Myeloproliferative Neoplasms

Flashcards about myeloproliferative neoplasms (MPN)

What are myeloproliferative neoplasms (MPN)?

Rare and life-threatening blood cancers caused by the overproduction of red blood cells, white blood cells, or platelets.

What are the synonyms for myeloproliferative neoplasms(MPN)?

Chronic myeloproliferative neoplasms and myeloproliferative disorders.

What are myeloproliferative neoplasms (MPN)?

Rare and life-threatening blood cancers caused by the overproduction of red blood cells, white blood cells, or platelets.

What are the synonyms for myeloproliferative neoplasms(MPN)?

Chronic myeloproliferative neoplasms and myeloproliferative disorders.

What are the three most common types of MPN?

Polycythemia vera, essential thrombocythemia, and primary myelofibrosis.

What is Polycythemia vera?

The excess red blood cells makes blood thick, so blood moves more slowly through your bloodstream.

What is Myelofibrosis?

The bone marrow produces abnormal stem cells that become inflamed and make scar tissue.

What is Essential thrombocythemia?

The bone marrow makes too many platelets.

What is Chronic eosinophilic leukemia (CEL)?

The overproduction of white blood cells called eosinophils.

What is Chronic myelogenous leukemia (CML)?

An overproduction of white blood cells called granulocytes.

What age groups are most commonly affected by Myeloproliferative neoplasms?

People in their 50s, 60s or older.

What Mutations are associated with Janus kinases (JAK)?

Polycythemia vera, primary myelofibrosis and essential thrombocythemia often involve genetic mutations associated with a protein called Janus kinase 2 (JAK2).

What are the Lab tests to diagnosis MPN?

Complete blood count (CBC), Peripheral blood smear (PBS), Blood chemistry tests, Bone marrow biopsy and Genetic testing.

What are the things to look for in Bone marrow biopsy?

Differences between normal and abnormal cells, unusual number of stem cells, changes in chromosomes and other signs of genetic mutations that may indicate a specific type of myeloproliferative neoplasm.

What is the only known cure for MPN?

Allogeneic stem cell transplantation.

What are the managements (or treatments) for MPN?

Reducing the number of blood cells, providing symptom relief and preventing complications.

What factors can affect experiences of MPN?

The type of myeloproliferative neoplasm, how early the diseases was diagnosed and how to respond to treatment.

What is the Chronic myelogenous leukemia (CML)?

The effectiveness of new targeted therapies has significantly increased the survival rate associated with CML.

What is Chronic neutrophilic leukemia (CNL)?

The overproduction of white blood cells called neutrophils.

What is Myeloproliferative neoplasm, unclassifiable (MPN-U)?

A type of myeloproliferative neoplasm that doesn’t fit into the other categories. It may involve an overproduction of various blood cell types, including white blood cells, red blood cells or platelets.