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absent, decreased, or excess coagulation factors may lead to a
clotting abnormality
two pathways for clotting
intrinsic pathway
extrinsic pathway
intrinsic pathway is activated when
plasma comes in contact with damaged vessel surfaces
extrinsic pathway is activated by tissue injury
when tissue thromboplastin, a substance released by damaged endothelial cells, comes in contact with one of the clotting factors