L24 Benzodiazepine

Pharmacological effect of benzodiazepines

Anxiolysis (inhibits anxiety)

Anticonvulsive effect

Spinal cord mediated relaxant

Primary benzodiazepines use in vet med

First line against seizures

Prevents ketamine associated muscle rigidity

What receptor does benzodiazepines target

GABAa only (primary inhibitory NT of CNS)

*facilitates GABA binding by enhancing affinity

What is responsible for the difference in effect in different species with benzodiazepines

The several subunits of the GABA receptor

Pharmacodynamic effect of benzos

Excitement but varies with age size & species

Benzodiazepines examples

Diazepam

Midazolam

Lorazepam

Zolazepam

If you want to use a benzodiazepine with a fat onset & long duration, which would you choose

Diazepam

If you want to use a benzodiazepine with a fast onset & short duration, which would you choose

Midazolam

If you want to use a benzodiazepine with a moderate onset & duration, which would you choose

Lorazepam

If you want to use a benzodiazepine with a long duration, which would you choose

Zolazepam

MOA for acepromazine

non dopaminergic effect

antiadrenergic that causes hypotension

acts on Alpha 1 & 2 receptor

acepromazine indications

preanesthetic

acepromazine contraindications

it has antihistaminergic effects making it unsuitable for allergic skin testing patientsa

azaperone

swine tranquilizer