Drugs for Hypothyroidism - PBsci 7

Levothyroxine (T4)

Synthetic T4 that is converted to active T3 to restore normal hormone levels

Levothyroxine (T4)

Side effects of over-replacement include palpitations, arrhythmias, and osteoporosis

Levothyroxine (T4)

Safe in pregnancy but dose often needs to be increased by 30-50%

Levothyroxine (T4)

The standard and recommended treatment for hypothyroidism during pregnancy

Liothyronine (T3)

Synthetic active T3 with rapid onset but short half-life

Liothyronine (T3)

Risk of thyrotoxicosis and arrhythmias

Liothyronine (T3)

Should be avoided in pregnancy due to potent effects and fluctuating levels

Desiccated thyroid extract

Contains both T4 and T3 in variable ratios from animal sources

Desiccated thyroid extract

Has variable potency and can cause allergic reactions

Desiccated thyroid extract

Not recommended in pregnancy due to unpredictable T3 content

Combination T4/T3 preparations

Replace both T4 and T3 hormones simultaneously

Combination T4/T3 preparations

Carry risk of thyrotoxicosis similar to liothyronine

Combination T4/T3 preparations

Not preferred