Inhibition and MM

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Last updated 5:03 PM on 5/22/26
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4 Terms

1
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Competitive Inhibition

def: the inhibitor structurally resembles the substrate and competes for the same active site on the free enzyme

  • binds to E complex

  • inhibitor can be overcome if a big amount of substrate is added

  • Vmax= Unchanged

  • Kmax= Increased

  • lines intersect on the y-axis

<p>def: the inhibitor structurally resembles the substrate and competes for the same active site on the free enzyme</p><ul><li><p>binds to E complex</p></li><li><p>inhibitor can be overcome if a big amount of substrate is added</p></li><li><p>Vmax= Unchanged</p></li><li><p>Kmax= Increased</p></li><li><p>lines intersect on the y-axis</p></li></ul><p></p>
2
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Noncompetitive Inhibition

def: the inhibitor binds to a different site (allosteric site), not the active site

  • can bind to the E complex or ES complex

  • can not be overcome since substrate binding is not inhibited, so Vmax is permanently reduced

  • Vmax= Decreased

  • Km= Unchanged

  • lines intersect on the x-axis

<p>def: the inhibitor binds to a different site (allosteric site), not the active site</p><ul><li><p>can bind to the E complex or ES complex</p></li><li><p>can not be overcome since substrate binding is not inhibited, so Vmax is permanently reduced </p></li><li><p>Vmax= Decreased</p></li><li><p>Km= Unchanged</p></li><li><p>lines intersect on the x-axis</p></li></ul><p></p>
3
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Uncompetitive Inhibition

def: inhibitor only binds to the ES complex, NEVER THE FREE ENZYME

  • when the substrate binds to the active sire, it causes a conformational change in the enzyme, then the inhibitor recognizes and binds to the newly exposed site on the enzyme

  • inhibition increases when more substrate is added since ES formation would increase; giving the inhibit more target to bind to

  • same slopes and both intercepts change proportionally

  • Vmax= DECREASES

  • Km= DECREASES

<p>def: inhibitor only binds to the ES complex, NEVER THE FREE ENZYME</p><ul><li><p>when the substrate binds to the active sire, it causes a conformational change in the enzyme, then the inhibitor recognizes and binds to the newly exposed site on the enzyme</p></li><li><p>inhibition increases when more substrate is added since ES formation would increase; giving the inhibit more target to bind to </p></li><li><p>same slopes and both intercepts change proportionally </p></li><li><p>Vmax= DECREASES</p></li><li><p>Km= DECREASES</p></li></ul><p></p>
4
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