skeletal muscle

muscle cells can be classified as [ ] or [ ]

striated, non-striated

skeletal muscle is [ ] and has [ ] on the periphery of the cell

striated, nuclei

skeletal muscle has a [ ] mode of contraction

voluntary

skeletal muscle is made of [ ], [ ] and [ ] connective tissues

endomysium, perimysium, and epimysium

the four types of tissue are [ ], [ ], [ ], and [ ]

connective tissue

muscular tissue

epithelial tissue

nervous tissue

skeletal muscle is widely distributed throughout the body, it is [ ] to the skin and hypodermis

deep

skeletal muscles are attached mainly to bone except for [ ] and [ ]

muscles of facial expression

intrinsic tongue muscles

the hierarchy of the structures in skeletal muscle is?

epimysium » perimysium » endomysium » sarcolemma » nucleus » sarcoplasm » myofibril

the connective tissue around muscle is known as [ ]

epimysium

connective tissue that surrounds fasicles (group of muscle cells)

perimysium

the connective tissue that is around a muscle cell / myofiber is [ ]

endomysium

the muscle cell plasma membrane is the [ ]

sarcolemma

the muscle cell cytoplasm is known as [ ]

sarcoplasm

sarco-, myo-, and -mysium mean muscle

[ ] are cord-like where [ ] is more of a sheet

tendons, aponeurosis

tendons/aponeurosis are fibrous and [ ]

non-contractile and inflexible

[ ] inform the CNS about changes muscle stretch and tension

Proprioceptive sensory organs

[ ] detect stretch while [ ] detect tension

muscle spindles, golgi tendons

the golgi tendon organ detecting tension is a [ ]

protective feedback mechanism

a [ ] is a bundle of skeletal muscle fibers

fascicle

fascicles are surrounded by perimysium and contain [ ] and [ ]

collagen and elastin

the [ ] is composed of reticular fibers and contain capillaries, nerve fibers, and stem cells for repair

endomysium

the [ ] and [ ] are composed of dense irregular connective tissue

epimysium and perimysium

from top to bottom, the arrows are pointing at ?

1) muscle cell nuclei

2) fibroblast nuclei

3) endomysium

the arrows are pointing to?

1) fibroblast nuclei

2) capillaries

3) endomysium

4) muscle cell nuclei

[ ] synthesize proteins to make up myofilaments

myotubes

a portion of the myoblast population does not fuse but instead differentiate into [ ]

satellite stem cells

[ ] are organized bundles of sarcomeres that are surrounded by sarcoplasmic reticulum with an abundance of mitochondria distirbuted around myofibrils

myofibrils

the parts of this myofibril include?

Z line

M line

Thin filament

Thick filament

the [ ] is the basic contractile subunit of skeletal muscle

sarcomere

the [ ] is the dark band that contains thick and thin filaments

A band / Anisotropic band

the [ ] is the light band containing only thin filaments

I band / Isotropic band

the area between the M line and Z disc is known as the [ ] containing only thick filaments

H zone

the attachment site for thick filaments is the [ ]

M line

the area where two thin filaments connect and transverse I bands is called [ ]

Z disc

the [ ] is held constant while the [ ] and [ ] bands narrow

A-band

I-band / H-band

striations are produced by the arrangement of the [ ], [ ], and [ ]

myofibrils, sarcomeres, myofilaments

the three major proteins in skeletal muscle include [ ], [ ], and [ ]

G-actin

Tropomyosin

Troponin

[ ] is the filamentous protein that binds to actin and covers myosin binding site

Tropomyosin

the function of Troponin T (Tnt) is to ?

anchor troponin complex to tropomyosin

the function of Troponin I (Tni) is to ?

inhibit filament interaction

it covers myosin binding site with tropomyosin

the function of Troponin C (Tnc) is to?

bind calcium for initiation of contraction

Myosin is composed of 6 polypeptide chains, 2 of which are [ ] and 4 that are [ ]

heavy

light

the heavy chains have a [ ] structure and form the “tail” of myosin

alpha helical

the light chains of myosin [ ] and contain a [ ]

bind to actin, ATPase site

[ ] prevent treadmilling or “cap them”

accessor sarcomere proteins

[ ] connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane

Dystrophin

[ ] caps the plus end of actin filaments where [ ] caps the minus end

CapZ

Tropomodulin

[ ] regulates thick filament length where [ ] regulates thin filament length

Titin

Nebulin

the picture is showing?

A Normal Person

Someone with Duchenne Muscular Dystrophy

A carrier of DMD

the transverse tubule system contains [ ], [ ], [ ], and [ ]

Sarcolemma

T-Tubule

Sarcoplasmic Reticulum

Terminal Cisternae

skeletal muscle contraction is initiated by direct contact at [ ]

somatic-motor- neuron axon terminals

[ ] in the synaptic cleft degrades ACh ending the stimulus and allowing the sarcolemma to repolarize

Acetylcholinesterase

[ ] and [ ] are caused by neurotoxins

Botulism and Tetanus

botulism is characterized by [ ] whereas tetanus is characterized by [ ]

flaccid paralysis

spastic paralysis

[ ] is a chronic autoimmune neuromuscular disease where antibodies are directed against acetylcholine receptors

Myasthenia Gravis