Aspirin Synthesis,Acylation mechanism and Acylchlorides,

Give 2 chemicals that can react with salicylic acid that creates Aspirin

Ethanoic anhydride Or Acyl chloride

Suggest 3 reasons why ethanoic anhydride is used instead of acyl chloride

Using acylchloride will produce a corrosive gas as a byproduct

Less expensive

Less reactive so it’s easier to control the rate of reaction

Why is phosphoric acid used in Aspirin synthesis?

To be a catalyst

Suggest why water is added in Aspirin Synthesis

It will hydrolyse any remaining reactants, to remove impurities.

Explain why air is sucked through the apparatus for 5 minutes

To dry the product and remove all the water or solvent

What are the steps to name an Acylchloride?

1. Count the number of Carbons in the R group

2. Add the suffix -oyl chloride

3. If it is branched count from the Acyl functional group to assign its number, place it at the front

Draw the mechanism of the adulation of ethanoylchloride and Ammonia and name the products formed

Draw the fully displayed structure of 2methylbutanoylchloride

Name this compound

Ethanoyl Chloride

Name this compound

Butanoyl chloride

If ethanoyl chloride reacts with ammonia what are the products produced?

Ethanamide and HCL in the gaseous state and is corrosive

Why are acylchlorides so reactive?

Because of the polarity of the chlorine and the oxygen. Causing the carbon to become very positive making it susceptible to attack.