642- KIDs List Table 1

Key PIMs in Pediatrics

ARBs (-sartans)

renal tubular dysgenesis

atazanavir

Kernicterus

camphor (topical)

seizures

ceftriaxone

kernicterus

chloramphenicol

gray baby syndrome

chlorhexidine (topical)

chemical burn

topical CSs

cushing syndrome, adrenal suppression

darunavir

seizures, death

dicloxacillin

kernicterus- CAUTION in younger than 1 mo

dicyclomine

apnea

diphenoxylate and atropine

respiratory failure, death

First gen antipsychotics

acute dystonic reactions, hyperprolactinemia

prochlorperazine

acute dystonic reactions

second gen antipsychotics

withdrawal, emergent dystonia/dyskinesia, TIIDM, weight gain, dyslipidemia, metabolic syndrome, hyperprolactinemia

promethazine

respiratory failure, death, acute dystonic reactions --> AVOID in younger than 2 yr, CAUTION in 2-18 yr

benzocaine (topical)

methemoglobinemia - AVOID oral application in younger than 2 yr

lidocaine (topical)

CNS depression, seizures, arrhythmia, death- AVOID in younger than 2 yr

Gentamicin (ophthalmic)

severe ocular reactions- AVOID in younger than 1 mo

Linaclotide

dehydration

lamotrigine

skin rashes (ranges from benign to life threatening)

loperamide

ileus, lethargy- AVOID in younger than 3 yr

macrolides (azithromycin, erythromycin)

hypertrophic pyloric stenosis- AVOID in younger than 1 mo except B. pertussis or C. trachomatis

midazolam

severe intraventricular hemorrhage, periventricular leukomalacia, death

mineral oil

lipid pneumonitis

montelukast

sleep disturbances- CAUTION in 18 yr and younger

naloxone

seizures

nitrofurantoin

hemolytic anemia- AVOID in younger than 1 mo

Codeine

respiratory failure, death

meperidine

acute neurotoxicity

tramadol

respiratory failure, death

propofol

propofol- related infusion syndrome- AVOID doses >4 mg/kg/hr

salicylates

reye syndrome

sodium phosphate (enema, rectal)

electrolyte abnormalities, AKI, arrhythmia, death

sodium polystyrene sulfonate

colonic perforation

sulfonamides

kernicterus

tetracyclines

tooth discoloration- CAUTION in younger than 8 yr, enamel hypoplasia, retardation of skeletal development

tricyclic antidepressants

sudden cardiac arrest- AVOID in 18 yr and younger

valproic acid

pancreatitis (fatal)

verapamil

cardiovascular collapse