DENTAL PHARMACOLOGY

ATROPHINE

• Treatment of cholinergic poisoning

• Unstable bradycardia

SCOPOLAMINE

motion sickness

BENZTROPINE

extrapyramidal side effect 1

TRIHEXPHENIDYL

extrapyramidal side effects 2

OXYBUTYNINE

overactive bladder

DICYCLOMINE

irritable bowel symdrome

GLYCOPYRROLATE

sialorrhea, surgical heart rate control

IPRATROPIUM

COPD/asthma

BETHANECHOL

urinary retention

CARBACHOL

decreases intraocular pressure in glaucoma

METHACHOLINE

bronchial asthma challenge test

PILOCARPINE

• sjogren’s syndrome (no salivation)

• dry eyes (lacrimination)

• cystic fibrosis (sweat test)

PHYSOSTIGMINE

atropine overdose

PHYRIDOSTIGMINE

myasthenia gravis treatment

EDROPHONIUM

myasthenia gravis diagnosis

DONEPEZIL

alzheimer’s disease

Division of nervous system

• Central nervous system

• Peripheral nervous system

NORADRENALINE

Involved neurotransmitter in sympathetic nervous system

ACETYLCHOLINE

Neurotransmitter involved in parasympathetic nervous system

enumerate dumbells

• Diarrhea (diaphoresis) and abdominal cramps

• Urination

• Miosis

• Bradycardia

• Lacrimation

• Lethargy

• Salivation

D,U,E,L,S

by product of body fluids, body fluids that go out.

NICOTINE

nicotinic is responsive to ___

IONOTROPIC RECEPTORS

• Ligan-gated receptors

• Nicotinic

Nn (neural) and Nm (muscular)

Nicotinic receptors

Autonomic ganglia

Location of Nn (neural)

GANGLIONIC TRANSMISSION

Agonist action of Nn (neural)

SKELETAL NEUROMUSCULAR JUNCTION

Location of Nm (muscular)

SKELETAL MUSCLE CONTRACTION

Agonist action of Nm (muscular)

M1, M2,M3,M4,M5

Muscarinic receptor

MUSCARINE

Muscarinic is responsive to ___ (protein)

METABOTROPIC RECEPTOR

• G-protein coupled receptor

• Muscarinic

NERVOUS SYSTEM

Location of M1,M4,M5

PROCOGNITIVE

Agonist action of M1,M2,M3

ANTICOGNITIVE

Antagonist action of M1,M4,M5

HEART

Location of M2

BRADYCARDIA

Agonist action of M2

TACHYCARDIA

Antagonist action of M2

• URINARY TRACT

• GASTROINTESTINAL TRACT

• EXOCRINE GLAND

• EYE

• AIRWAYS

Location of M3

BLADDER CONTRACTION AND RELAXATION

Agonist and antagonist action of M3 urinary tract

INCREASED AND DECREASE PERISTALSIS

Agonist and antagonist of M3 gastrointestinal tract

INCREASE AND DECREASE SECRETION

Agonist and antagonist action of M3 EXOCRINE GLANDS

MIOSIS AND MYDRIASIS

Agonist and antagonist action of M3 EYE

BRONCHOCONSTRICTION AND BRONCHODILATION

Agonist and antagonist action M3 AIRWAYS

PARASYMPATHOLYTICS/ANTI-PARASYMPATHOMIMETICS

“anticholinergic” is under of ___

• ATROPINE

• SCOPOLAMINE

• BENZTROPINE

• TRIHEXPENIDYL

• OXYBUTYNINE

• DICYCLOMINE

• GLYCOPYRROLATE

• IPRATROPIUM

ENUMERATE ALL THE DRUGS OF ANTICHOLINERGIC

PARASYMPATHOMIMETIC

“cholimimetics” or “cholinergic” is under of ___

DIRECT AND INDIRECT MUSCARINIC AGONIST

PARASYMPATHOMIMETIC is divided in to two muscarinic agonist

ACETYLCHOLINESTERASE

Indirect muscarinic agonists inhibits what enzyme?

• BETHANECHOL

• CARBACHOL

• METHANECHOL

• PILOCARPINE

Enumerate drugs in DIRECT MUSCARINIC

• PHYSOSTIGMINE

• PYRIDOSTIGMINE

• EDROPHONIUM

• DONEPEZIL

enumerate drugs in INDIRECT MUSCARINIC