ANTHRANILIC ACID, HIS, PSEUDO, PURINE

• quinazoline

• furoquinoline

• acridine

what are the alkaloid class derived form anthranilic acid?

quinazoline, anthranilic acid

name, origin

anthranilic acid, ornithine

in quinazoline, what are the sources of N?

furoquinoline, anthranilic acid

name, origin

skimmianine, furoquinoline, anthranilic acid

name, alkaloid class, origin

acridine, anthranilic acid

name, origin

rutacridone, acridine, anthranilic acid

name, origin alkaloidal class

imidazole, histidine

name, origin

• glaucoma

• cholinergic muscarinic receptor agonist — causes myosis and outflow of aqueous humor

pharmacologic use of jaborandi leavese (pilocarpine, pilosine, etc)

• acetate-derived

• phenylalanine

• terpenoid

• steroidal

classes under pseudoalkaloids

n-methyl coniine, acetate derived pseudoalkaloid

• NOT A PIPERIDINE!

name, origin, alkaloidal class

muscular paralysis, convulsions

pharmacological use of poison hemlock

ephedrine, phenylalanine derived pseudoalkaloids

name, origin, class

false (its precursor is L-Phe but the amine group is later added via transamination)

true or false: the amine group in ephedrine is from L-Phe

• CNS stimulant, sympatomimetic, acts on α- & β-adrenergic receptors

• Addictive, hallucinations, paranoia, psychosis

pharmacologic use of ephedrine

gentianine, terpenoid derived pseudoalkaloid

name, origin, class

gentianine

this terpenoid derive pseudoalkaloid is mostly found as artefact formed when the plant is treated with NH3 that contains gentiopicroside

gentiopicroside

gentianine is a terpenoid derive pseudoalkaloid is mostly found as artefact formed when the plant is treated with NH3 that contains?

solanine, steroidal pseudoalkaloid

name, origin, class

• theophylline

• theobromine

• caffeine

purine alkaloids

name, class origin

• caffeine

• theobromine

• theophylline

identify the purine alkaloid:

• more potent stimulant, least potent diuretic

• low stimulant, more diuretic, smooth muscle relaxant

• low stimulant, effective diuretic, best smooth muscle relaxant

saxitoxin, purine alkaloid, L-Arg

name, origin class

saxitoxin

Na+ -channel blocker that causes paralytic shellfish poisoning

tetrodotoxin

Found in internal organs or skin of puffer fish, inhibits voltage-gated Na+

-channel and causes diaphragm paralysis, respiratory failure

tetrodotoxin, purine alkaloids, L-Arg + IPP

name, origin class