HISTONE H1 MUTATIONS IN LYMPHOMA (Page 34-35)

; [Which Histone H1 coding genes are recurrently mutated in B-cell lymphomas?]

HIST1E, HIST1C, and HIST1D (also referred to as HISTH1E, HISTH1C, HIST1D in some sources).

; [Where do these mutations tend to cluster?]

Mutations tend to cluster in the globular domain of the histone H1 protein and affect dyad formation in the nucleosome.

; [How are these mutations thought to drive cancer development?]

Through dysregulation of 3D genome architecture and loss of normal histone modification deposition throughout the genome.

; [Can Histone H1 mutations drive cancer alone?]

Yes. Mouse models of Histone H1 mutations show that they can drive cancer formation alone.

; [What is the combined effect of Histone H1 mutations and BCL2 overexpression?]

Histone H1 mutations combined with BCL2 overexpression leads to a more severe survival rate in the mouse mod