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Nervous system
Is composed of two main types of cells: neurons and glia
Neurons
Cells specialized for communication using electrical and chemical signals
Glia
Cells that support neuronal signaling, provide nutrients, guide neurons in development and perform other support functions
Gene Expression
The type and functions of nervous system cells are defined by their
Neuron
A specialized cell for communication using electrical and chemical signals
Synapse
The site where communication between neurons occurs
Brain 2% and uses 25%
The human brain energy use
86 billion
Number of human neurons
Afferent
A message toward the brain; sensory neurons
Sensory Neuron
A neuron that carries sensory information toward the central nervous system
Efferent
A message away from the brain: motor neurons
Motor neuron
A neuron that carries information away from the central nervous system to muscles
Interneuron
A neuron that sends message between neurons
Dendrites
Parts of a neuron that receive information
Cell body/Soma
The main part of the neuron containing the cell’s nucleus and other cellular compenents
Axon
The part of the neuron through which the electrical signal spreads
Axon Terminals
The ends of an axon that release neurotransmitters to synaptic partners
Myelin Sheath
An insulating covering axon that prevents ion leak and helps action potentials travel rapidly
Node of Ranvier
Gaps in the myelin sheath that are densely packed with ion channels
Glia
Means “never glue.” Make up about 30-60% of total brain mass and support neuronal signaling, provide nutrients, and guide neurons in development.
Astrocytes
Glial cells involved in development, energy and metabolism, synaptic functions, and maintenance of the blood-brain barrier
Microglia
The “immune system” in the brain; they eliminate synapses and provide signaling to other cells
Oligodendrocytes
Glial cells that myelinate the central nervous system
Schwann Cells
Glial cells that myelinate the peripheral nervous system
Central Nervous System (CNS)
The brain and spinal cord
Peripheral Nervous System (PNS)
The peripheral motor and sensory nerves
Somatic Nervous System
The part of the peripheral nervous system containing sensory nerves that carry information to the CNS and motor nerves that carry information from the CNS to muscles
Sensory Nerves
Nerves that carry information to the central nervous system
Motor Nerves
Nerves that carry information from the central nervous system to the muscles
Autonomic Nervous System
The part of the peripheral nervous system involved in automatic bodily functions includes the sympathetic and parasympathetic nervous system
Sympathetic Nervous System
The division of the autonomic nervous system responsible for the fight-or-flight response
Parasympathetic Nervous System
The division of the autonomic nervous system responsible for rest and digest
12 cranial nerves
This amount of cranial nerves that enter and exit directly from the brain. They innervate the face, head, and neck, plus the vagus nerve
Neural Circuit
A group of neurons connected by synapses that process specific types of information
Patellar Reflex
A stretch of the patellar tendon causes the quadriceps muscle to stretch. Sensory nerves send a signal to the spinal cord, where sensory nerves synapse directly onto the motor neurons. Motor neurons fire, causing the quadriceps to contract and the lower leg lift
Simple Reflex Circuit
A circuit in which sensory information travels to the spinal cord and activates motor neurons to produce a rapid response
Bilateral Symmetry
The left and right hemispheres of the brain and spinal cord are nearly mirror images
Meninges
Protective layers around the brain and spinal cord
Dura Mater
The outer layer of the meninges
Arachnoid Mater
The middle layer of the meninges
Pia Mater
The inner layer of the meninges
Spinal cord
A functionally organized part of the central nervous system that carries sensory and motor information
Dorsal Horn
The part of the spinal cord containing sensory interneurons
Ventral Horn
The part of the spinal cord containing motor neurons
Dorsal Root
A bundle through which axons carrying sensory information emerge from the spinal cord
Ventral Root
A bundle through which axons carrying motor information emerge from the spinal cord
Mixed Nerve
A nerve containing both sensory and motor axons
Spinal Cord tracts
Pathways that carry sensory and motor information to and from the brain
31 spinal nerves
Amount of pairs of nerve bundles containing many axons that exit between the vertebrae
Cerebrospinal fluid (CSF)
Fluid that cushions and protect the brain, exchanges material between the blood and brain, and found in the ventricular system and subarachnoid space
Choroid Plexus
A tissue suspended in the ventricles and produces cerebrospinal fluid
Ventricular System
The system of brain ventricles through which cerebrospinal fluid flows
Subarahnoid Space
The space where cerebrospinal fluid found around the brain and spinal cord
Vascular System
The system provides nutrients and energy and carries away waste
Gray Matter
Brain and spinal cord tissue containing bodies and dendrites
White Matter
Brain and spinal cord tissue containing myelinated axons
Neuronal Communication
Both electrical and chemical
Action potential
An electrical signal that spreads through a neuron across the axon and triggers transmitter release to the neuron’s synaptic partners
Neurotransmitter
A chemical signal released by a neuron to transfer information between neurons and exicte, inhibit, or modulate the activity of neurons
7,000
Typical neuron Synaptic Partners
400
Neuronal Message Rate
Presynaptic Terminal
The axon terminal of the neuron that stores and releases neurotransmitter
Postsynaptic Terminal
The receiving part of the neuron, typically a dendrites
Synaptic Cleft
The space between the presynaptic and postsynaptic neruons where neurotransmitters are released
Vesicle
A small structure in the presynaptic terminal that stores neurotransmitters
Receptor
A protein that recognizes and binds a specific neurotransmitter
Presynaptic Neuron
The neuron that releases neurotransmitter into the synaptic cleft
Postsynaptic Neuron
The neuron that receives neurotransmitter through postsynaptic receptors
Storaged Neurotransmitter
Are stored in vesicles in the presynaptic terminal
Glutamate
A neurotransmitter that can excite neurons
GABA
A neurotransmitter that can inhibit neurons
Dopamine, serotonin, norepinephrine
A neurotransmitter that can modulate neuronal activity
Receptor binding
A neurotransmitter binds to postsynaptic receptors and produces an electrical change in the receiving neuron
Excitatory postsynaptic potential (EPSP)
A brief electrical change that excites a neuron and makes an action potential more likely
Inhibitory postsynaptic potential (IPSP)
A brief electrical change that inhibits a neuron and makes an action potential less likely/
Electrical Synapse
A synapse in which connexon physically bridges two neurons and allows both electrical signals and small molecules to pass between neurons in both directions
Connexon
A structure that physically bridges two neurons at an electrical synapse
Threshold
The membrane potential that must be reached for an action potential to be triggered
Parallel Processing
Information spreads along multiple pathways
Feedback
Neurons influence their own inputs
Rhythmicity
Repeating patterns of neuronal activity
Balance
Excitation and inhibition
Reverberatory Activity
Activity that allows neurons to stay active for longer periods of time and help maintain in working memory
Divergent Connections
Connections in which a small number of neurons broadcast a message to large number of recipients
Midbrain Dopaminergic Neurons
An example of neurons with divergent connections that broadcast messages to many recipients
Convergent Connections
Connections in which many different neurons send signals to a small number of recipients neurons
Electrochemical Force
Forces that influence the movement of ions across a cell membrane, including electrical and diffusion forces.
Electrical Potential
The separation of charge produces an electrical potential across the membrane. It is measured in volts.
Current
The flow of charge over time. It is measured in amps
Conductance
The amount of ion flow allowed through channels; the more channels open, the higher it is. It is measured in siemens.
Membrane Potential
The electrical inside of cell relative to the outside of the cell
Electrode
A device used to measure electrical potential inside cells relative to outside
-70
Resting membrane potential approximately what number
Ion
A charged particle that can generate current in neurons
Sodium (Na+), Potassium (K+), Calcium (Ca2+), Chloride (CI-)
An ion that is present at a high concentration outside a typical neuron
Extracellular fluid
The fluid outside fo a typical neuron that is high in Na+, CI-, Ca2+
Intercellular fluid
The fluid inside a typical neuron that is high in K+
Diffusive force
Produced by a difference in concentration that pushes ions from areas of high concentration toward areas of low concentrations
Electrostatic Force
A forc cause electrical charges attracts opposite charges and repels like charges
Ion Pump
A protein machine that uses energy to move ions against their concentration gradient