Chapter 15 - The Fate of Retrieved Memories

Retrieval Processes

Processes that influence how memories are accessed and remembered.

Destabilization Function

The claim that retrieving a memory puts it in a vulnerable, labile state.

Integrative Function

The role of the brain in assessing and combining new content with previously acquired information.

Cue-Dependent Amnesia

A phenomenon where retrieval cues lead to the forgetting of associated memories.

Active Trace Theory

The theory that memories exist in either short-term active states or long-term inactive states.

Reconsolidation Theory

The theory that previously consolidated memories can be re-stabilized after retrieval.

Labile State

A temporary state in which a memory is vulnerable to disruption and alteration.

Engram

The physical representation of a memory in the brain.

Calcium Levels in Spine Compartment

Increased calcium levels that are crucial for memory trace destabilization.

Ubiquitin-Proteasome System

Cellular mechanism that degrades proteins and mediates memory trace destabilization.

Stimulus Pairing

The association made between a conditioned stimulus (CS) and an unconditioned stimulus (US).

Protein Synthesis Inhibitor

A substance that disrupts the synthesis of proteins necessary for memory consolidation.

Prediction Error

A discrepancy between expected outcomes and actual outcomes that can destabilize memories.

Temporal Window

A period during which reactivated memory traces remain destabilized, allowing for integration.

AMPA Receptor

A receptor involved in mediating synaptic transmission and memory retention.

NMDA Receptor

A receptor that is critical for synaptic plasticity and memory formation.

Antisense Treatment

A method used to block the translation of specific genes involved in memory reconsolidation.

Drug Relapse Cycle

The cycle of drug use leading to addiction and potential relapse upon encountering drug-related cues.

Conditioned Stimulus (CS)

A stimulus that elicits a response due to its association with an unconditioned stimulus.

Long-Term Memory (LTM)

The phase of memory storage that is more stable and less vulnerable than short-term memory.

Short-Term Memory (STM)

The phase of memory storage that is temporary and more susceptible to disruption.