Selective Serotonin Reuptake inhibitor (SSRIs)

drugs in class

fluoxetine (Prozac)

paroxetine (Paxil)

sertraline (Zoloft)  **

italopram (Celexa)

escitalopram (Lexapro)

properties/MOA

·       Safer than TCAs

·       Produces selective inhibition of serotonin reuptake

(more remains in synapsis)

effects/adverse rxn

·       DOES NOT CAUSE:

→ hypotension

→ sedation

→ anticholinergic effects

·       Sexual dysfunction

·       Weight gain

·       HA

·       N/V

·       Serotonin Syndrome

→ Occurs when used w/triptans or SSRI OD

contraindications

Contraindicated w/ Triptans, MAOIs, warfarin, TCAs, and lithium

 

Sertraline OK if nursing

 

Fluoxetine less suicide risk

nursing info

·       Most popular antidepressant

·       Used for Hypersexuality (ex. Child Molestation)

·       Work for depression plus many anxiety disorders

→ PTSD, OCD, GAD, PD, SAD