Allosteric Control of O2 Transport by Hemoglobin

These flashcards cover key vocabulary and concepts related to the allosteric control of oxygen transport by hemoglobin, incorporating definitions and important mechanisms discussed in the lecture.

Bohr Effect

Describes how a decrease in pH in tissues compared to lungs leads to decreased O2 saturation.

T State

The tense conformation of hemoglobin that has lower affinity for O2.

R State

The relaxed conformation of hemoglobin that has higher affinity for O2.

2,3-BPG

A negative heterotropic regulator that stabilizes the T state of deoxyhemoglobin.

Protonation of His146

Leads to ionic bonding that stabilizes the T state of hemoglobin.

Carbamate Formation

The generation of a carbamate group on the N-terminal residue (Val) of hemoglobin, contributing to the Bohr effect.

Carbonic Anhydrase

An enzyme that hydrates CO2 to form bicarbonate and releases H+, lowering tissue pH.

O2 Saturation Curves

Graphs that compare the oxygen saturation of fetal and adult hemoglobin at different partial pressures of oxygen.

Negative Allosteric Regulators

Molecules like CO2, H+, and 2,3-BPG that decrease hemoglobin's affinity for O2.

Fetal Hemoglobin

Has a higher O2 affinity than adult hemoglobin due to lower affinity for 2,3-BPG.