Malignant Neoplasm (SARCOMAS) (56-63)

1. Cellular morphology of sarcoma

2. Nuclear feature of sarcoma cells

3. Differentiation status of sarcoma cells

Pleomorphic cells vary in size and shape

Hyperchromatic nuclei

Poorly differentiated or anaplastic

1. Mitotic activity in sarcoma

2. Abnormal mitotic feature observed

Numerous mitoses

Very large abnormal mitotic figure

1. Immunohistochemical marker for sarcoma

2. Contrast between sarcoma cells and muscle fibers

Vimentin

Stained = sarcoma

1. Gross appearance of osteosarcoma

2. Site of origin in bone

Large, bulky mass extending outward

Cortex

1. Cellular composition of osteosarcoma

2. Histologic feature confirming osteosarcoma

Spindle cells

Pink osteoid formation indicating differentiation

1. Common sites of liposarcoma

2. Gross appearance of liposarcoma

3. Clinical behavior of liposarcoma

Retroperitoneum and thigh

Large yellowish mass resembling adipose tissue, well-differentiated

Indolent but progressive growth, tendency to recur after excision

1. Cell of origin in liposarcoma

2. Cellular feature of neoplastic cells

Adipocyte

Pleomorphism of lipoblasts

1. Microscopic feature of liposarcoma

2. Preferred treatment of sarcomas

3. Response of sarcomas to chemo/radiation

Large bizarre lipoblasts

Surgical excision

Variable