Malignant Neoplasm (SARCOMAS) (56-63)

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8 Terms

1
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<ol><li><p>Cellular morphology of sarcoma</p></li><li><p>Nuclear feature of sarcoma cells</p></li><li><p>Differentiation status of sarcoma cells</p></li></ol><p></p>

  1. Cellular morphology of sarcoma

  2. Nuclear feature of sarcoma cells

  3. Differentiation status of sarcoma cells

Pleomorphic cells vary in size and shape

Hyperchromatic nuclei

Poorly differentiated or anaplastic

2
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<ol><li><p>Mitotic activity in sarcoma</p></li><li><p>Abnormal mitotic feature observed</p></li></ol><p></p>

  1. Mitotic activity in sarcoma

  2. Abnormal mitotic feature observed

Numerous mitoses

Very large abnormal mitotic figure

3
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<ol><li><p>Immunohistochemical marker for sarcoma</p></li><li><p>Contrast between sarcoma cells and muscle fibers</p></li></ol><p></p>

  1. Immunohistochemical marker for sarcoma

  2. Contrast between sarcoma cells and muscle fibers

Vimentin

Stained = sarcoma

4
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<ol><li><p>Gross appearance of osteosarcoma</p></li><li><p>Site of origin in bone</p></li></ol><p></p>

  1. Gross appearance of osteosarcoma

  2. Site of origin in bone

Large, bulky mass extending outward

Cortex

5
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<ol><li><p>Cellular composition of osteosarcoma</p></li><li><p>Histologic feature confirming osteosarcoma</p></li></ol><p></p>

  1. Cellular composition of osteosarcoma

  2. Histologic feature confirming osteosarcoma

Spindle cells

Pink osteoid formation indicating differentiation

6
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<ol><li><p>Common sites of liposarcoma</p></li><li><p>Gross appearance of liposarcoma</p></li><li><p>Clinical behavior of liposarcoma</p></li></ol><p></p>

  1. Common sites of liposarcoma

  2. Gross appearance of liposarcoma

  3. Clinical behavior of liposarcoma

Retroperitoneum and thigh

Large yellowish mass resembling adipose tissue, well-differentiated

Indolent but progressive growth, tendency to recur after excision

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<ol><li><p>Cell of origin in liposarcoma</p></li><li><p>Cellular feature of neoplastic cells</p></li></ol><p></p>

  1. Cell of origin in liposarcoma

  2. Cellular feature of neoplastic cells

Adipocyte

Pleomorphism of lipoblasts

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<ol><li><p>Microscopic feature of liposarcoma</p></li><li><p>Preferred treatment of sarcomas</p></li><li><p>Response of sarcomas to chemo/radiation</p></li></ol><p></p>

  1. Microscopic feature of liposarcoma

  2. Preferred treatment of sarcomas

  3. Response of sarcomas to chemo/radiation

Large bizarre lipoblasts

Surgical excision

Variable