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Last updated 11:53 PM on 3/2/26
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57 Terms

1
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soft tissue injuries

sprains

  • strains

  • dislocations

  • subluxations


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sprain

abnormal twisting

  • stretching of joint or spinal musculature

  • injury to ligaments

    • can’t see ligaments on XRAY.. might need MRI

  • commonly in the ankle or knee

  • classified in grades

    • grade 1 = stretching/small tears

    • grade 2 = larger tears

    • grade 3 = complete tear


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strains

muscle, fascial sheath, or tendon

  • stretched or torn

  • can palpate a torn muscle

  • very painful

  • firm but extremely tender


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dislocations

a complete separation of bones in a joint

  • most clear sign → deformity

  • presentation: orthopedic emergency, chance of severe vascular damage

  • complications: avascular necrosis → dislocation resulted in blood supply cut off to joints, compartment syndrome

  • treatment: closed reduction, surgical open reduction, immobilization

  • nursing interventions: PERFUSION ASSESSMENTS, pain relief, support of joint, protection of joint, restrict motion/gentle ROM, rehabilitation


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sublaxations

a partial or incomplete dislocation where joint surfaces remain partially in contact, often slipping back into place

  • bones in joint aren’t aligned properly but still in contact

  • presentation: partial or incomplete displacement of joint, less severe

  • treatment: closed reduction, surgical open reduction, immobilization but with less healing time

  • nursing interventions: PERFUSION ASSESSMENTS, pain relief, support of joint, protection of joint, restrict motion/gentle ROM, rehabilitation


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sprains/strains

strain = muscular tissue

  • sprain = ligaments

  • clinical manifestations

    • pain

    • edema → swelling

    • decrease in function/weakness

    • ecchymosis

    • spasms

  • diagnostics

    • x-ray, MRI to r/o fracture or joint damage

  • complications

    • joint structure is unstable → tearing of ligaments that hold bones together

    • avulsion fracture → ligament has disconnect some of the bone from itself, so if ligament is pulled so severely, it can pull some of the bone away

    • hemoarthrosis → blood in the joints, can cause dysfunction and pain

    • long-term instability

  • interventions

    • prevention: stretching, warming up, strength training, balance training

    • treatment: stopping the activity, RICE (24-48 hours)

      • rest, ice, compression, elevate

    • pain relief → NSAIDs/acetaminophen, don’t give narcs

    • heat & movement > 48 hours


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repetitive strain injuries (RSI)

  • catch-all term for symptoms and signs located in the neck, upper back, shoulder, arm, elbow, hand, wrist, and fingers

  • risks:

    • repetitive activities

    • high-intensity activity for long time w/o rest

    • poor posture/awkward position

    • computer use

    • overtraining for sports

  • interventions:

    • correct precipitating factor

    • modify behvaior

    • pain management: NSAIDs, heat/cold application

    • rest

    • PT

    • ergonomics

    • lifestyle modifications


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carpal tunnel syndrome

etiology: compression of median nerve

  • most common neuropathy of UE

  • risk factors:

    • female hormone imbalances & smaller carpal tunnels

    • cancer → fluid shifts + hormone imbalances

    • RA → inflammation and swelling around carpal tunnel

    • ganglion cysts → little cysts that live on the joints, cause compression of median nerve

    • DM → impacts perfusion, impacts neurovascular process

    • PVD → impacts perfusion, impacts neurovascular process

    • continous wrist movement

  • assessment:

    • weakness

    • burning pain

    • numbness

    • impaired sensation

    • tinel’s sign → tap on median nerve. positive response = sensation of tingling over the median nerve & shooting/tingling pain

    • phalen’s sign → allow wrist to fall freely and maintain position longer than 60 seconds. if compressed carpal tunnel → tingling of median nerve. see atrophy of thumb muscle and overall hand dysfunction

  • interventions:

    • prevention: good ergonomics

    • TX: relieve cause

      • early: stop activity, modification, hand splint

      • later: cortisone injection for anti-inflammatory to decr inflammation around carpal tunnel, PTanti-inflammatory

      • >6 months: carpal tunnel release Sx.. done if symptoms are lasting more than 6 months or if there is significant impairment to median nerve. open release surgery.


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fractures

  • A partial or complete break in a bone

  • etiology:

    • traumatic

    • pathologic → like cancer


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fracture classifications


  • open → open to environment and bone is exposed. traumatic force to cause this. infection risk is higher

  • closed → not open to the environment


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fracture extent

  • complete

    • break goes completely through the bone

    • 2 sides are not connected

  • incomplete

    • fracture is partly across bone shaft, but bone itself is still intact

    • fracture, but 2 ends of the bone are still connected


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fracture displacement

  • displaced

    • two ends of broken bone are separated from each other

    • out of normal position

    • more tissue injury than non-displaced

    • comminuted

      • fracture with more than 2 fragments

      • caused by crush injury

      • fragments are free floating

      • seen more in severe trauma and falls from great heights

      • very complicated and requires more healing

  • non-displaced

    • bone fragments are in alignment

    • transverse: bone breaks in a straight line, perpendicular to its long axis

    • spiral: fracture line coils around the bone like a corkscrew

    • greenstick: incomplete bone break where bone bends and cracks on one side only. commonly occurs in children due to flexible bones

    • oblique: diagonal break across a bone’s long axis

    • stress: occurs in bones that are subjected to repeated stress


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clinical manifestations of a fracture

  • edema

    • cause: disruption/penetration through skin/soft tissues/bleeding

    • significance: occlude circulation, nerve damage, compartment syndrome

  • pain

    • cause: trauma, spasm, pressure, movement of fracture

    • significance: reduction in motion

  • spasm

    • cause: irritation and protection

    • significance: displacement

  • deformity

    • cause: abnormal position

    • significance: signals fx, prevent union

  • ecchymosis

    • cause: extravasation of blood

    • significance: distal to injury, resolves

  • loss of function

    • cause: disruption

    • significance: address to preserve ability to restore function

  • crepitation

    • cause: crunching of fragments

    • significance: possible non-union, micromovement = osteogenesis


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fracture care goals

  • REALIGN, IMMOBILIZE, RESTORE FUNCTION

  • closed reduction

    • nonsurgical, manual realignment, traction, casting, splints, external fixation, braces

    • nothing broken thru skin

    • do the least invasive procedure first due to risks w post-op

  • open reduction (ORIF)

    • surgical, internal fixation

    • disadvantages: risk for infection, anesthesia complications, comorbid disease


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fracture healing steps

1. hematoma

  • bleeding at the site

  • creates semi-solid clot ~72 hrs after injury

  • sanguineous drainage = bloody drainage


  • 2. organization into fibrous network

    • good new blood vessels, osteoblasts to form basis for new bone substance

    • maintain immobilization so don’t break fibers

  • 3. osteoblasts mobilize, calcium deposits

    • calcium and magnesium help new bone form

  • 4. callus formation

    • temporary thickened structure of cartilage and bone forms to stabilize the break

  • 5. remodeling

    • hard, temporary callus is replaced by strong bone

    • takes 3 days - 6 months to get through this.. comply w immobilization and instructions/limitations



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fracture cast healing

  • materials

    • plaster

      • cheaper, easier to mold

    • fiberglass

      • lightweight, stronger, water resistant, preferred

    • poly/cotton

    • 3-D printed

  • allow for ADLs

  • variations

    • short arm:

      • stable wrist and metacarpal

    • long arm:

      • stable forearm/elbow, unstable wrist

    • body jacket:

      • stable spine

      • monitor for cast syndrome (small bowel obstruction)

      • compression of mesenteric artery cuts off blood flow to bowel

      • severe pain, pressure, N/V to abdomen

  • hip spica:

    • pelvis and one or both legs

  • long leg:

    • tibia, femur

  • short leg:

    • foot, ankle

  • cylinder:

    • knee or lower leg

  • jones dressing/jones cast dressing:

    • sterile foot dressing


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fracture patient education

  • do

    • elevate first 48 hours → decr swelling

    • watch for 6 P’s

    • apply ice in plastic bag

    • if gets wet → dry completely with a hair dryer on low

    • hair dryer cold and diphenhydramine for itching

    • move joints above/below cast

  • do NOT

    • get cast wet (unless waterproof)

    • insert items into or remove parts

    • bear weight for 48 hours

    • stick anything into the cast (between cast and skin)

  • other

    • pain meds:

      • muscle relaxants

      • NSAIDs

      • opioids

    • other meds (open fracture)

      • tetanus and diptheria

      • cephalosporins

    • nutrition

    • options for mobility

    • no smoking


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what are the 6 P’s?

  • pain

  • paresthesia

  • paralysis

    • nerves can’t transmit impulses

  • pallor

    • poor capillary refill

  • pulselessness

    • pulse is extremely weak

    • use doppler

  • poikilothermia

    • tissue is cold


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traction

  • pulling force to affected area; counter-traction pulls in opposite direction

  • pressure to distal to align with proximal

  • also helps with healing → hematoma is forming and if can’t take to surgery soon, use this to start helping put bone in right area to promote healing

  • purpose:

    • prevent/reduce pain, spasms

    • immobilize area

    • fx reduction

    • treat pathology

  • types of traction:

    • skin traction

    • skeletal traction

    • external fixation


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skin traction

  • short-term treatment

  • tape, boots, splints

  • maintains alignment

  • assists in reduction

  • diminishes muscle spasms

  • weights typically 5 or 10 pounds except pelvis

  • ex) buck’s traction

    • dependent on positioning & alignment of patient - laying in bed of sitting up in chair

    • must keep traction forces on at all times → only time to remove is in life threatening/limb threatening situation

    • no weights touching floor → must hang freely

    • weight must move freely thru pulleys → no knots


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skeletal traction

  • longer treatment → maybe person can’t go get surgery for several weeks

  • treats fractures, contractures (extreme tightening of muscle)

  • wire/pin inserted into bone

  • immobilizes

  • weights = 5 to 45 pounds

    • attaching weight to wires/pins

    • can hold much more weight and be in place longer

  • disadvantages:

    • infection, consequences of immobility


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external fixation

  • metal pins & wires inserted into bones

  • attached to external rods

  • provides stabilization while fracture heals

  • used for complex fractures, bony defects, limb lengthening

  • increased risk for infection

  • requires pin care

    • hydrogen peroxide and gauze


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complications of healing - infection


  • high incidence

  • devitalized/contaminated tissue is growth medium

    • anaerobic bacteria

    • leads to increased cost/risk for morbidity

  • treatment:

    • aggressive surgical debridement

    • IV antibiotics for 7 days-6 weeks-6 months

  • warmth, fever, swelling, purulent drainage, bright red erythema


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complications of healing - union problems

  • bones have not healed properly together

  • if person is at high risk for this, surgeon may not operate

  • nonunion (pseudoarthritis)

  • malunion

  • causes of delayed union and nonunion

    • poor blood supply

    • insufficient nutrients

    • insufficient immobilization

    • metabolic disorders: DM, PVD

    • smoking


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complications of healing - compartment syndrome

  • can be caused by fractures, severe trauma, casts that are too tight, tight dressings

  • medical emergency

  • etiology:

    • internal

      • hemorrhage

      • swelling

      • fluid

    • external

      • tight dressings

      • tight casts

  • manifestations

    • 6 P’s

      • pain

      • pallor

      • pulselessness

      • paresthesia

      • poikilothermia

  • interventions

    • do not elevate limb, keep at heart level → want to promote blood flow to the area

    • no cold packs → don’t wanna decr blood supply

    • remove or loosen bandages, split cast → don’t wanna worsen blood flow

    • monitor BP, prevent hypotension

    • O2 to maximize saturation

    • urgent surgical consult (fasciotomy)

      • cut into fascia and release pressure → allow room for swelling to occur

      • releases pressure on nerves and blood vessels

      • allows tissues to be perfused

      • high risk of infection → use antibiotics

      • assess for neurovascular intactness → get baseline and check frequently


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complications of healing - VTE

  • common causes

    • surgery → venous stasis causes clots and blood can’t go back to heart..

    • clot can travel to heart and lungs to be deadly

    • fracture of hip, pelvis, long bones

    • multiple trauma

    • immobility → muscles aren’t contracting → venous stasis, so no blood going back to heart

    • prior VTE

    • venous stasis

    • hypercoagulable state

      • could be from a med

    • endothelial injury

      • during surgery → vessels are cut

  • S&S

    • thigh/calf pain or tenderness

    • UNILATERAL EDEMA

    • warm to touch

    • red streaks/discoloration

  • general interventions:

    • prevent and treat

      • heparin/enoxaparin

      • early immobilization of fracture

      • early ambulation

      • compression stocking

      • SCDs - sequential compression devices


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complications of healing - myositis ossificans

  • calcification in soft tissue

  • new bone forms in muscle tissue after injury - healing process occurs in wrong place

  • usually from trauma

  • tx:

    • ROM exercises to loosen area and maintain functionality

    • strengthening

    • ESWL (extracorporeal shockwave lithotripsy)

      • using shock waves to break apart bone tissue

  • sx:

    • pain with movement

    • swelling

    • limited ROM

    • hard palpable lump in affected muscle/tissue


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complications of healing - fat embolism

  • embolisms can travel to heart and lungs and cause major issues

  • release of fat globules that break off and enter bloodstream

  • emboli = moving

  • thrombus = stationary

    • once thrombus is broken off and starts moving, it becomes an emboli

  • long bone break (tibia, femur, ribs, pelvis) leads to release of marrow

    • when breaks of long bones → incr risk of fat globules being released into the bloodstream

    • fat drop becomes stuck in small vessels → ischemia occurs at distal capillaries

  • hormonal changes caused by trauma can stimulate release of free fatty acids

  • can mimic other complications like pulmonary embolism

  • can happen in young and old people

  • factor in many fracture deaths

  • risks:

    • total joint replacement

    • spinal fusion

    • liposuction

    • crush injuries

    • bone marrow transplan

  • common MS causes:

    • multiple fx

    • fx of long bones

    • hip replacement

  • S&S

    • 24-48 hours after fx

      • LOC changes - poor O2 exchange

      • confusion

      • restlessness

      • dyspnea

        • respiratory depression signs bc fat doesn’t belong in pulmonary vasculature of lungs

      • tachypnea

      • tachycardia

      • fever

      • petechiae

        • microhemorrhages → fat globules have landed in capillaries and caused breakage

      • hypoxia

  • interventions

    • prevention is key

    • early stabilization of long bones

    • patient education at D/C

    • promote lung expansion

    • oxygen IVF

    • monitor respirations

    • TCBD, repositioning

    • possible intubation & mechanical ventilation


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complications of healing - osteomyelitis

  • severe infection: bone, marrow. periosteum

  • usually see it a few months after surgical intervention

  • infection in the bone

  • etiology:

    • open fracture

    • prosthetics

    • periodontal disease, UTI, TB, puncture wounds, infectious pathogens

  • risk factors:

    • trauma, open wounds, immunocompromised pts, vascular insufficiency, prosthetic devices

  • manifestations

    • acute < 1 month

      • usually local

      • bone pain unrelieved by rest, increased with activity, swelling, tenderness, warmth, decreased ROM

    • chronic > 1 month

      • local and sytemic

      • fever, chills, night sweats, nausea, malaise

  • diagnostics

    • history & physical

    • labs

      • WBCs, ESR, CRP

      • soft tissue or bone biopsy, blood/wound culture

      • x-rays, bone scans, MRI/CT

  • interventions:

    • acute

      • IV ABs - long term course, 6 week to 6 months

      • surgical debridement

      • AB irrigation

      • AB acrylic beads implanted in bone

    • chronic

      • IV ABs

      • surgeries

        • incision/drainage

        • debridement

        • sequestrectomy

        • bone graft

        • amputation - sometimes the best, safest option

      • hyperbaric O2


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complications of healing - avascular necrosis

  • common MS causes:

    • interruption of blood supply to bone by fx → bone death, non healing

    • most common with long bones (hip, talus, femur at knee joint)

    • not an infection…

  • S&S, Dx

    • pain

    • decreased sensation

    • MRI diagnosis

  • general interventions:

    • surgery

    • sometimes bring in new bone


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assessment of fracture

  • compare affected side with contralateral side

  • assess distal to fracture

  • vascular assessment

    • if not neurovascularly attached - could have necrotic tissue

    • skin color → supposed to be pink

    • skin temp → supposed to be warm

    • pulse → supposed to be palpable

    • cap refill → supposed to have under 3 secs

  • neuro assessment

    • movement

    • sensation

    • pain

      • neuro pain not gonna work w opioids


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surgery: preoperative

  • standard pre-op workup

  • educate regarding immobilization device

  • activity limitations

  • assurance of assistance

  • pain control available

  • skin preparation


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surgery: postoperative

  • monitor VS

  • NV checks

    • paralysis

    • paresthesia

    • pulse

    • cap refill

  • monitor positioning

    • turning, moving

  • monitor for compartment syndrome

  • monitor for drainage & bleeding

  • PT/OT


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hip fractures

  • super common in elderly

  • 90% are fall-related

  • by age 90:

    • 30% of females and 20% of males will have hip fx

  • 30-50% die within a yr due to complications of fx, immobility

  • potential long-term dsiability

  • due to decr muscle strength, altered reflexes, and meds that incr fall risk


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classification of hip fx

  • intracapsular

    • within the joint capsule

    • higher risk of avascular necrosis

    • capital

    • subcapital

    • transcervical

  • extracapsular

    • outside of joint capsule

    • intertrochanteric

    • sub trochanteric

  • femoral neck

    • also incr risk of avascular necrosis


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hip fracture manifestations

  • external rotation

  • muscle spasm → give muscle relaxants

  • shortening of affected extremity

  • severe pain & tenderness at site


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hip fracture treament

  • temp bucks traction

    • reduces spasms

  • surgical repair

    • allows early mobilization

    • decreases risk of complications


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hip fracture interventions

  • preoperative

    • assess co-morbidities

    • muscle spasm reduction

    • teach

      • proper exercise unaffected side

      • overhead trapeze/handrail use

  • postoperative

    • monitor VS, I&O

    • respiratory

    • monitor wound damage

    • assess extremity


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hip fracture post-op care

  • regular assessments:

    • Vs

    • Is&Os

    • respiratory

      • TCDB → turn cough deep breathe

      • post surg patient at high risk of pneumonia bc meds depress breathing, not moving around, not breathing deeply

      • fluid gets caught in lungs

    • pain

      • wanna get up and moving

      • pain meds can help

    • check dressing/site

  • assess for complications:

    • hip dislocation

    • infection

    • bleeding

  • positioning

    • OOB day of or day after surgery

    • avoid turning to affected side

    • overbed trapeze

    • abductor pillow

    • do not let leg cross midline

    • don’t cross legs or bend joints greater than 90 degree angles

  • physical therapy

  • placement needs


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osteoarthritis pathophysiology

  • cartilage destruction → wear and tear

  • joint space narrows

  • bone-on-bone

  • crepitation

  • osteophytes (bone spurs)

  • joint pain, stiffness, decreased mobility, muscle atrophy


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osteoarthritis characteristics

  • chronic

  • progressive

  • degenerative

  • unilateral, can progress to bilateral

    • if on one side, body compensates and eventually can affect other side

  • non-systemic

    • localized inflammation/pain

    • shouldn’t be seeing it in places other than the joints


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risk factors of osteoarthritis

  • trauma

  • inflammation

  • joint instability

  • mechanical stress

  • skeletal deformities

  • lack of exercise

  • obesity

  • aging

  • drugs


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osteoarthritis joints involved

  • weight-bearing

    • hips

    • knees

    • spine

    • hands


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osteoarthritis physical assessment

  • morning stiffness that goes away within an hour

  • joint pain - worsens as day goes on

    • early: goes away w rest

    • later: doesn’t go away w rest

  • acute to chronic pain

  • muscle spasms

  • crepitus

  • deformity (hands): bony growth at joint. debilitating and interferes with mobility

    • heberden’s nodes

    • bouchard’s nodes

  • psychosocial changes r/t pain, disability


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osteoarthritis diagnostics

  • XRAY, MRI, CT

    • detect joint space narrowing, bony sclerosis, osteophyte formation

  • bone scan

    • detects bone growth, regeneration


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osteoarthritis assessment

  • history

  • physical

  • impact on ability to perform ADLs

  • pain management beliefs, practices

  • physical exam of joints

    • compare with contralateral joint


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osteoarthritis goals

  • maintain or improve joint function

  • not much else u can do to reverse other than joint replacement

  • use joint protective measures

  • achieve independence in self care and maintain optimal role function

  • use drug and non-drug strategies to manage pain


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osteoarthritis interventions

  • medication

    • ASA

    • APAP

    • NSAIDs

    • topical creams

  • non-pharm pain mgt

    • acupuncture

    • yoga

    • massage

    • guided imagery

  • balance rest/activity

    • rest during acute inflammation

    • modify activities to decr joint stress

    • avoid prolonged standing, kneeling, squatting (knee OA)

  • diet & exercise

    • dietary changes PRN

    • aerobic

    • ROM

    • quad strengthening

  • assistive devices

    • splinting

    • support

    • cane/walker

  • temperature therapy

    • ice for inflammation

    • heat for stiffness


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osteoarthritis patient education

  • pain mgt

  • body mechanics

  • corrective use of assistive devices

  • joint protection and energy conservation

  • nutrition

  • weight and stress management

  • exercise


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osteoarthritis support

  • assure deformity is not usual course of OA

  • therapy, support groups

  • community resources - www.arthritis.org


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rheumatoid arthritis pathophysiology

  • chronic, systemic autoimmune disease, inflammation of connective tissue in synovial joints

    • body attacks own cells

    • damage caused by inflammation

  • all ethnic groups, across lifespan, peak 30-50 yo

  • 1.3 million americans

  • women > men (2-3x)

    • see higher incidence in women

  • 1. precipitating event (antigen)

  • 2. autoimmune response

  • 3. inflammatory cascade

  • 4. synovial inflammation

  • 5. cartilage and bone damage

  • 6. formation of rheumatoid nodules

  • 7. systemic effects


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rheumatoid arthritis S&S

  • early

    • nonspecific

    • joint inflammation

    • fatigue

    • aching

    • morning stiffness - 1 hr or longer

    • low-grade fever bc immune system active and thinks something is wrong

  • later

    • moderate to severe pain

    • joint softness, swelling

      • inflammatory process happening

      • red and swollen all the time

    • joint tenderness

    • muscle atrophy → weakness bc avoiding use of joint

    • systemic S&S

      • SQ nodules

      • osteoporosis

      • vasculitis

      • sjorgren’s syndrome

        • immune system attacks moisture-producing glands → causes dry eyes and mouth with more joint pain

    • joint deformities

      • boutonniere

      • swan neck

      • ulnar deviation


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rheumatoid arthritis manifestations

  • boutonniere deformity

  • ulnar deviation

  • swan neck deformity of fingers

  • extra-articular manifestations

    • RA is a systemic disease → manifestations that happen outside of the joints

    • rheumatoid nodules

      • 25% RA

      • SQ, firm, nontender, usually on extensor surface joints

      • usually not removed bc they just come back

      • if in lungs, sclera, poorer prognosis

    • sjorgrens syndrome

      • secondary to RA or independent d/o

      • 10-15% RA

      • diminished lacrimal/salivary secretions

      • dry mouth, gritty, and burning eyes

      • decreased tearing and photosensitivity


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rheumatoid arthritis diagnostics

  • HPI and physical findings

  • labs

    • WBC > 20k (mostly neutrophils)

    • + RF (rheumatoid factor) in 80%

    • elevated ESR (erythrocyte sedimentation rate), CRP (C-reactive protein)

      • inflammatory markers

      • when these are elevated → body is in process of systemic inflammation

    • ANA (anti-nuclear antibodies)

    • anti-CCP (anti-cyclic citrullinated peptides)

    • four of the following:

      • morning stiffness > 1 hr

      • swelling in 3+ joints

      • swelling in hand joints

      • symmetric joint swelling

      • erosions on hand x-rays

      • rheumatoid nodules

      • serum RF


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rheumatoid arthritis interprofessional team goals

  • prevent deformity

  • decrease inflammation

  • pain management

  • maintain function

  • increase mobility


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rheumatoid arthritis interventions

  • acute

    • drug therapy

    • medication teaching

    • rest

    • joint protection

    • lightweight splints

    • ROM exercises

    • occupational therapist

    • plan care around pain

  • home care

    • stress management

    • balance nutrition

    • alternate rest with recovery

    • avoid total bed rest

    • modify activities to avoid overexertion

    • avoid flexion position

    • individualize exercise plan


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rheumatoid arthritis meds

  • NSAIDs & anti-inflammatory

    • APAP and ibuprofen

  • DMARDs - disease modifying antirheumatic drugs

    • non-biologics

      • methotrexate → decreases progression of joint deformity and erosion

      • lower risk of toxicity. slows and helps suppress immune system

      • puts pt at risk of infections

      • avoid crowds

      • avoid illness

      • avoid ETOH

    • BRMs

      • modifies specific parts of immune system to help slow it down

      • most TNF blockers

      • etanercept (enbrel)

      • adalimumab (humira)

      • infliximab (remicade)

  • flare-ups

    • corticosteroids

      • systemic

      • local: intraarticular steroids

      • immune suppression → incr risk of infection

    • NSAIDs

    • topical analgesics

  • give immediately and consistently to slow disease progression and decrease risk of joint deformity

    • DMARDs

      • lessen joint erosions and deformity

      • chosen based on RA progression, functional level, lifestyle, cost

    • methotrexate

      • fewer sx in days to weeks, lower cost, fewer SEs

      • bone marrow suppression, hepatotoxicity, iatrogenic birth defects

      • lab monitoring: CBC, chem panel

  • given when flare-ups/exacerbations occur

    • corticosteroids (provide sx relief and immune suppression)