Immunoserology Test 1

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B-cells mature where?

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Bone marrow

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T-cells are produced in:

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Thymus

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42 Terms

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B-cells mature where?

Bone marrow

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T-cells are produced in:

Thymus

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Prozone

too much antibody

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Lymphocytes

T and B cells, adaptive immunity

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affinity

antibody and antigen single strength

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avidity

combination strength

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long-lasting antibody

IgG

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1st seen antibody, pintomer

IgM

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IgM to IgG

class switching

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MHC 2- suppressor and T-cell helpers

CD4

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MHC 1- cytotoxic

CD8

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antigen presenting cells

Dendritic cells

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Fab

antigen binding

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Fc

Antibody binding (epitope)

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Fx of antibodies

opsonization, neutralize, active complement

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Humoral immunity

insoluble (abs, compl., Cytokines)

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Cellular immunity

T-cells, B-cells, neutrophils

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Active immunity

Ab against ag, long lasting

Natural- having Hep B and recovering

Artificial- getting Hep B vaccine

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Passive immunity

Ab delivered to host, short acting

Natural- mother to child through nursing

Artificial- immunoglobulin shot to prevent rabies virus

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Precipitation

2 soluble - insoluble

Ag+ Ab = Clumps. arcs

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Agglutination

latex RBC's, hemaglutination

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RPR

flocculation

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Single diffusion

ab/ag diffuse

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double diffusion

Ag and ab diffuse, Duchterlony

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Nephlometry

light scatter, measure at an angle

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EIA

enzyme immunoassay

substrate- color change

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Primary response

IgM, low IgG, short acting, long lag

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Secondary (amnestic)

IgG, long lasting, shorter lag

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Specific

false positive

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Sensitive

false negatives

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IgA

tears, mucosal tissues, saliva, dimer

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IgD

cord blood, unknown

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IgE

allergies responses, parasitic infections, sensitize/ activate mast cells

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IgG

Protects newborns, most common, activates complement/ opsonization

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IgM

1st antibody produced, pentamer, acute immune response

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MHC II- CD4 T cells

Helper T cells

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MHC I- CD8 T cells

Cytotoxic T cells

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Antibody structure

2 Fab regions (bind to ag) and

1 Fc region (ab binds- epitope)

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Hypersensitivity reaction; Type 1

Allergic reactions, IgE

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Hypersensitivity reaction; Type 2

Cytotoxic, IgG/ IgM

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Hypersensitivity reaction; Type 3

Immune complex reactions, IgG/ IgM, AGN and glomerulonephritis

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Hypersensitivity reactions; Type 4

Cell mediated, T-cells