TUMORS OF NERVE TISSUE ORIGIN - NEURAL LESIONS

1. TRAUMATIC NEUROMA

Transection of a sensory nerve can result in inflammation and scarring in the area of injury.

1. TRAUMATIC NEUROMA

As the proximal nerve segment proliferates in an attempt to regenerate into the distal segment, it becomes entangled and trapped in the developing scar

1. TRAUMATIC NEUROMA

Microscopically, bundles of nerves in a haphazard or tortuous arrangement are found admixed with dense collagenous fibrous tissue; a proliferation of nerve fascicles embedded in a collagenous stroma.

SCHWANNOMMA - Neurilemmoma

. As the lesion grows, the nerve is pushed aside and does not become enmeshed within the tumor

SCHWANNOMMA - Neurilemmoma

An encapsulated submucosal mass that presents typically as an asymptomatic lump in patients of any age.

SCHWANNOMMA - Neurilemmoma

Homogeneous tumors, consisting only of Schwann cells; tumor cells always stay on the outside of the nerve, but the tumor itself may either push the nerve aside and/or up against a bony structure

NEUROFIBROMA

may appear as solitary lesions or as multiple lesions as part of the syndrome neurofibromatosis (von Recklinghausen’s disease of skin).

NEUROFIBROMA

overgrowth and disorganization of normal nerve tissue with the addition of inflammatory cells and blood vessels.

NEUROFIBROMA

Solitary neurofibroma presents at any age as an uninflamed asymptomatic, submucosal mass. The tongue, buccal mucosa, and vestibule are the oral regions most commonly affected

MULTIPLE ENDOCRINE NEOPLASIA SYNDROME – MEN Syndrome

Only MEN type III (also known as MEN 2b), inherited as an autosomal-dominant trait, has oral manifestations.

MULTIPLE ENDOCRINE NEOPLASIA SYNDROME – MEN Syndrome

affected individuals tend to be tall and lanky, with an elongated face and protruding, blubbery lips

MULTIPLE ENDOCRINE NEOPLASIA SYNDROME – MEN Syndrome

a genetic disease that causes multiple tumors the mouth, eyes, and endocrine glands

MALIGNANT PERIPHERAL NERVE SHEATH TUMOR

The cell of origin is believed to be the Schwann cell and possibly other nerve sheath cells;

MALIGNANT PERIPHERAL NERVE SHEATH TUMOR

It arises from a preexisting benign nerve sheath tumor (neurofibroma)

MALIGNANT PERIPHERAL NERVE SHEATH TUMOR

It demonstrates Schwann cell differentiation on histologic examination

MALIGNANT PERIPHERAL NERVE SHEATH TUMOR

can occur either spontaneously or in association with neurofibromatosis-1 (NF1).

GRANULAR CELL TUMOR

formerly known as granular cell myoblastoma, is an uncommon benigh tumor of unknown cause.