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Parts of the nervous system
Nervous system
Central nervous system
Peripheral nervous system
Brain
Spinal cord
What are sulci and gyri
The sulci are the grooves of the brain
The gyri are the humps of the brain
Longitudinal fissure, central sulcus, lateral fissure
Parts of the brain
Cerebral cortex
Frontal lobe
Temporal lobe
Parietal lobe
Occipital lobe
Cerebellum
Brain stem
What was found about split brain patients
Visual input from one side is processed in the other sides hemisphere (left visual information, right hemisphere)
The left hemisphere can do verbal processing so words flashed to the right side of the view can say what they see
The right hemisphere means they can draw what they see but not say it
Parts of the neurone
Dendrites
Terminal bulb
Cell body
Axon
Potentials of a neurone
Resting potential -70mv
Action potential 40mv
Hyperpolarisation -75mv
What is the all or none law
An action potential occurs or doesn’t
What is rate law
The strength of a stimulus is represented by the firing rate of an axon
What is depolarisation
Activation opens membrane channels
Sodium is moved in - depolarisation
What is action potential
Membrane potential is rapidly reversed and becomes strongly positive compared to the outside
Action potential converted into chemical signals
What is Hyperpolarisation
Potassium flows out of the cell and the membrane potential briefly drops, eventually sodium flows out of cell and potassium is recovered
What is the absolute refractory period
After AP occurred, no further APs can be triggered for a short time
AP travels in only on direction
Limit to possible APs 300/s
What did paul broca 1861 find
Patient tan
Left frontal lobe, lateral sulcus
Able to understand spoken language
But difficult or impossibilities formulating speech
Broca aphasia
What did Carl wernicke 1874 find
Wernicke aphasia
Left posterior, superior temporal gyrus
language comprehension impaired - meaningless speech
Speech retains a natural sounding rhythm and a relatively normal syntax
What are lesion studies
To draw conclusions about normal, intact cognitive processes from the patterns of impaired and intact capabilities seen in brain injured patients
Ellis and Young 1988
What is a double dissociation
When there are issues with the broca area and wernicke area
Causing impaired language production and impaired comprehension
Orientations/directions of the brain
Anterior (rostral) - front towards the nose
Posterior (caudal) - back towards the tail
Dorsal - towards the back
Ventral - towards the stomach
Medial - towards the middle
Lateral - towards the side
Superior - above/towards the top
Inferior - below/towards the bottom
What is atypical development
An enduring pattern of behaviour that is unusual compared to the behaviour of others of the child’s age, and that if interferes with the child’s development in some significant way - Bee & Boyd 2007
No simple way to define atypical behaviour
Norms help to distinguish typical and atypical
Atypical: violation of norms
Mental illness prevalence
10% of children & adolescents experience a mental disorder worldwide but the majority don’t seek help or receive care
Suicide is the fourth leading cause of death in 15-19 year olds
Many psychological disorders continue into adulthood
What is a risk
Child characteristics or experiences that increase the likelihood of negative development outcomes
Some children are more at risk
Acute and chronic risk factors
Examples of risk factors
Biological - genetic vulnerabilities, low birth weight, prenatal stress, prenatal exposure to toxins, parental psychopathology
Psychological - temperament difficulties, poor emotional regulation
Social/environmental - family conflict, neglect, low social support, socioeconomic disadvantage, poverty, homelessness, community disaster
What is resilience
Protective factors that help children adapt positively despite risk
Used to describe children who - avoid negative outcomes despite being at risk, display sustained competence under stress, show recovery from trauma
Examples of resilience factors
Individual - emotional competence, self regulation, cognitive abilities, easy temperament, high intelligence and scholastic competence, effective communication skills, positive self esteem and emotions, high self efficacy
Family - warm, consistent parenting, secure attachment, parental support
Social/community - positive peer relationships, school support, extracurricular engagement, religion
Masten & Coatsworth 1998 - protective triad - individual, family, extrafamilial context
Benefits of identifying risk and resilience factors
Early identification of risk and promotion of resilience can improve developmental outcomes
Interventions can target emotional skills, parenting practices, and social support to decrease risk of negative outcomes and atypical development
Gender differences of development
Developmental disorders more common on boys - minus depression
Girls protected from inherited disorder
Hormonal differences
Different treatment by parents
What are the three types of atypical development
Attentional problems - ADHD
Externalising problems - conduct disorder
Internalising problems - depression, anxiety, ED
(Also extreme IQ, falling behind in school, social impairments)
Diagnosis of ADHD
Attentional deficit hyperactivity disorder
Inattention, hyperactivity, impulsivity
Sections for attention and hyperactivity/impulsivity:
must be evident for at least six of five symptoms in either the inattention section or in the hyperactivity/impulsivity section
Difficult to measure prevalence
Estimate of 2-7% of children diagnosed worldwide
Boys more vulnerable
ADHD children are no different to typical children on a number of attention tasks - Lawrence 2004
Evidence for biological origin of ADHD
Successful treatment with methylphenidate
Parents with hyperactivity + twin studies - Thapar 2003
Brain structure and function is different - Kagan & Herschkowitz 2005
Diagnosis of externalising problems/conduct disorder
a pattern of behaviour that includes high levels of aggression, argumentativeness, bullying, disobedience, irritability and threatening and loud behaviour
Aggression against people and animals
Destruction of property
Theft or other violations of trust
Breaking major rules
What are the two types of externalising problems
Found by Hinshaw et al 1993
Childhood onset conduct disorders - severe aggression, more risk factors and vulnerability - Kochman 2005, behaviour can worsen
Adolescent onset conduct disorder - behaviour milder, hanging with bad company
Consequences of internalising problems
Interference with learning - Calhoun & Dickerson Mayes 2005
Drug use - Rey, Sawyer, Raphael, Patton & Lynsey 2002
Suicide - Fenning et al 2005
Causes for internalising problems/depression
Depressed parents - Marikangas & Angst 1995
Genetic factor or parent child interaction
Child depression a function of number of stresses
Any combination of stresses increases likelihood of depression in children - Chang 2001
What are the stages of physical development
Fertilisation of a female egg, genetic makeup is determined
1 month after conception - major organs begin to develop
around 25 days - beginning of a nervous system
At birth - brain reached 25% of adult weight
the brain mature and adapts, density of neural networks increase rapidly
6 months - brain reaches 50% of adult weight
5 years - brain reaches 90% of adult weight
neurons become better insulated, synapses form, association areas of the cortex mature and hemispheres become specialised
What are Piagets stages of development
Sensorimotor
Preoperational
Concrete
Formal operational
What is the sensorimotor stage
Birth to 2 years
Understands world through sensory and motor experience
Exhibits emergence of symbolic thought - starts acquiring language words to represent object
Object permanence
What is the preoperational stage
2-7 years
Language develops - uses symbolic thinking in the form of words and images to represent objects and experiences
Centration - focusing on the situation - conservation impaired
Egocentrism - children believe people perceive things the same way they do
What is the concrete operational stage
7-12 years
Thinks logically about concrete events
Grasps concepts of conversation and serial ordering
What is the formal operational stage
12+ years
Thinks more logically, abstractly, and flexible
Can form hypotheses and systematically test then
Evaluation of piagets model
Order of general cognitive ability development observed around the world
Children acquire some cognitive skills at an earlier stage
Cognitive development within each stage seems to proceed inconsistently
Cultural influence
Cognitive development is more complex and variable
What is the theory of mind (TOM)
Interpreting other people’s behaviours in terms of: beliefs, desires, intentions, imagination, emotions, perspective taking
Ability for empathy and understand if others
Developed around the age of 3-4 years
Premack & Woodruff 1978
What influences TOM
Understanding eye gaze and joint attention
humans rely on eye direction rather than head direction - Tomasello et al 2007
Recognising themselves in the mirror
Self awareness - Amsterdam 1972
Use mental state verbs
Acts of altruism
Desires are easier to represent than beliefs
What is the function of TOM
One of the major milestones in our evolution
Innate module for he mind evolved to understand other people - Baron-Cohen, Leslie & Frith 1985
Social groups
cooperation
empathy
prevent being taken advantage of
What are modules
Modules are evolved components of the mind that have specific functions
If something is a module it can be impaired leaving other functions intact
What is the sally anne task
False belief test - Wimmer & Perner 1983
Infants must understand that another’s beliefs can be different from their own - and can be incorrect
At 3 children find it hard to understand a belief is false
By 4 years old children can pass the test
understand perceptual contact importance
Evaluation of the false belief task
Is it too difficult
attentional demands
multiple participants in the scenario
TOM is more than false belief
2 year olds more likely to point to a toy they cannot reach for an adult who wasn’t present when the toy was placed on the shelf - O’Neill 1996
Children under 4 show many examples of understand others minds
What is autism described as
Characterised by persistent deficits in the ability to initiate and to sustain reciprocal social interaction and social communication and by a range of restricted, repetitive and inflexible patterns of behaviour, interests or activities that are clearly atypical or excessive for the individuals age and sociocultural context - ICD11
What is the prevalence of autism
1.1% in the UK, 1.85% in the US
1/160 children worldwide - 0.63%
4:1 male to female ratio
Women less likely to be diagnosed than males - Dworzynski et al 2012
There may be under or mis diagnosis of females, particularly those with higher IQs
Can those with autism pass the false belief test
Many autistic children cannot
Autism and TOM capabilities are very closely associated
accounts well for social interaction and some social communication
Does not explain all autism signs/symptoms and some children with autism have developed a TOM
What word does hormones come from
Greek word hormon
Which means to excite
What is a hormone
Chemicals which are stored and secreted by specialised glands in the body named endocrine glands
Travel through the bloodstream to their target region where they exert an effect
Act on the brain and the body very early development and during puberty to shape physiology and behaviour
As adults they continue to influence physiology and behaviour
What are the main endocrine glands
Pineal
Pituitary
Thyroid
Parathyroids
Adrenal
What did Berthold 1849 find
First endocrinological experiment
Castrated young roosters noted changes in behaviour and physiology
When testes were reimplanted the birds regained their normal behaviour and physiological development
Which two key structures control hormone release
Hypothalamus activated
Pituitary gland activated
What is the hypothalamus
Part of the diencephalon belonging to the forebrain
Nuclei synthesise releasing hormones that either stimulate or inhibit the release of hormones from the pituitary
What is the pituitary gland
The master gland
Produces at least 10 hormones which influence other endocrine glands
2 regions: anterior, posterior
What happens when there is a stimulus from sensory neurones
Sensory information from parts of the body travel to hypothalamus
Triggers secretion of hormones
Duration of 2-3 seconds
What happens in the process of feedback
Hypothalamus monitors hormone levels in the blood
Inhibits or secreted hormones as appropriate
What is testosterone
An androgen which is a class of hormones produced primarily in males
Regulate male sexual development and function
Sculpts the male genitals prenatally and maintains male secondary sexual characteristics
Promotes courtship, dominance and sexual behaviour
Name 2 other androgens
Dihydrotestosterone
Androstenedione
Research evidence for testosterone
Decreasing testosterone levels results in a decline in sexual interest and fantasy, and intercourse frequently in young males - Bagatell et al 1994
Injections of androgens significantly increase all aspects of sexual activity - Davidson et al 1982
Sexual activity increases levels of circulating testosterone - Hellhammer et al 1985
Positive association between testosterone levels in 18 year olds and number of sexual partners - Stulhofer et al 2019
What did Hirschenhauser et al 2002 find about testosterone
They found a relationship between high morning testosterone levels and sexual activity that night
Testosterone levels peaked at the weekend across their sample
Fathers and prospective fathers observed a 28 day cycle of testosterone levels, while unattached males and males not wanting to impregnate their current girlfriend did not
Testosterone and aggression
Certain species demonstrate a clear relationship between testosterone and aggression
Relationship is more complex in humans
Short term administration influences aggressive behaviour in high dominance men and those with lower cortisol levels - carre and archer 2018
Fluctuations in testosterone during competitive interactions are associated with aggressive responses - carre et al 2017
Effects may be modulated by context and social desirability factors - pante et al 2022
Testosterone, dominance, and competition
Testosterone is linked with dominance and competitiveness in humans - Mazur & Booth 1998
Winners show raised levels of testosterone from approximately 1-2 hours following competition
There is evidence that fans of a winning team can exhibit increased levels of testosterone
Evidence for a link between testosterone and the home advantage - Neave & Wolfson 2003
Increasing testosterone is associated with competitive endurance in males gaining enhanced status - Casto et al 2020
What is Estrogen
Sex steroid hormone
Regulate female sexual development and function
Estrogen hormones include estradiol, estrone and estriol
Promotes female secondary sexual characteristics
Involved in water retention, calcium metabolism and sexual and maternal behaviours
Fluctuates throughout the menstral cycle
Estrogen and emotional cognition
Estrogen has been linked to dopamine regulation and may play a role in female experiences of psychosis - Caroline & Kulkarni 2004
Higher levels of Estrogen may be associated with emotional coding and facial expression recognition - Chen et al 2011
Estrogen may play an important role in working memory in women - Hampson 2018
Salivary Estrogen has been associated with psychological outcomes, somatic distress during hormonal transitions, decision making and health compromising behaviours - Reider et al 2020
What is oxytocin
Labelled as the love hormone
Released during life experiences that involve emotional attachment
Located in several dopamine rich areas of the brain
Implicated in a variety of behaviours, including social bonding, parental care, and stress reduction
Associated with maternal bonding behaviours such as affectionate touch and vocalisations - Olazabal 2018
Administration of oxytocin can improve emotional recognition - Simplicio & Harmer 2016
What is cortisol
Increases glucose in the blood stream and helps to regulate metabolism, also impacts cardiovascular function
Diurnal - rises in the morning and decreases at night
Prolonged elevated cortisol levels have been associated with poorer performance in memory tasks and neuronal connectivity in the hippocampus - Ddonse et al 2023, Kim, Pellman & Kim 2015
What is leptin
May shed light on appetite control
Mice with a particular genetic defect, a defective ob gene, are unable to produce leptin and overeat
Injection of leptin reduce food intake in mice however such techniques have failed in obese humans
What are organisational effects of hormones
Occur during sensitive periods of development and permanently organise the brain and body in ways that influence later behaviour
What are activational effects of hormones
Occur throughout life when fluctuating hormone levels temporarily activate behavioural and physiological response
components of social identity theory
social categorisation - we sort people into groups
social identification - groups become part of self concept
social comparison - group memberships provide meaning and value
social support
emotional/informational/instrumental/companionship
shared identity increases trust and help seeking
collective self efficacy
groups enhance belief that we can cope, improving coping and problem solving
meaning, purpose & identity continuity
groups supply roles, narratives and life purpose that reduce existential stress
social norms & behaviour regulation
group norms shape healthy behaviour
cognitive appraisal & threat reframing
salient identities change how stressors are appraised
prototypicality and acceptance
feeling like a real member increases access to support and status within the group
mechanisms of social identity theory
social support
collective
meaning, purpose & identity continuity
social norm & behaviour regulation
cognitive appraisal & threat reframing
prototypicality and acceptance
the social cure framework - jetten 2017
proposition 1 - belonging to valued groups enhances psychological and physical health
proposition 2 - multiple group memberships provide additive resilience
proposition 3 - group processes mediate between identity and health - support, norms, efficacy
negatives for potential social identifications/social aids
not all identities are health enhancing - gangs, extremist groups can cause harm
identity conflict - competing group memberships can increase stress
stigma and marginalisation - belonging to a stigmatised group can undermine health
context matters - group support only helps if identity is shared and meaningful
What is the study of genetics
The study of the structure and function of genes and the way in which genes are passed from one generation to another - Russell 1992
What are the essential amino acids
Arginine
Histidine
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine
Threonine
Tryptophan
Valine
What are amino acids
Building blocks of life
Genes code for proteins
Amino acids - poly peptides - proteins
Maintain shape of cells
Tissues
Enzymes
Neurotransmitters
Who is the father of genetics
Gregor Mendel - 1822-1884
Looked into related organisms
8 years he planted 30,000 plants, set out to examine and quantify the physical traits in pea plants
Certain factors transmitted from parent to offspring
Mendel suggested that these factors were directly responsible for physical traits
Each individual had not one but two factors for each trait
What is Mendelian genetics
Hereditary transmission is a single pair of genes, one from each parent determines a particular inherited characteristic
Genes that control a particular trait can have alternative forms called alleles
When the corresponding genes inherited from the parents are the same, then the individual is homozygous for the trait
When the alleles are different, the individual is said to be heterozygous, for dichotomous traits they will display the characteristic described by the dominant allele
Mono hybrid cross

What are polygenic traits
There is no singular height or skin colour gene, there are many genes
Expression can depend on the precise compliment of different genes
Poly = many genes coding for one trait
Environmental factors can also contribute to phenotypic differences
The effects of gene may only be seen following some kind of trigger
What are chromosomes
Threat like structures in the nucleus of each cell - Brenner 2012
46 chromosomes - 23 pairs
Contained in the nucleus of every cell - minus gametes which only have 23 chromosomes
44 autosomal chromosomes, and 2 gender linked chromosomes
What is DNA
Deoxyribonucleic acid
Super folded molecule
Nucleotides: adenine, cytosine, guanine, thymine
Bases are linked as A-T and C-G
What is a codon
Combination of 3 nucleotides that code for one amino acid
What is behavioural genetics
“I do not know a single psychological trait that does not show genetic influence” - Plomin 2018
Heritability - the extent to which differences between individuals can be explained by inherited dna differences
Heritability estimates can differ depending in the particular population studies at a particular time
How are adoption studies used
Exploring correlations for psychical, psychological and behavioural traits between adoptive parents and children
Comparing correlation with those for biological parents
Comparing correlations with non adoptive children and parents
Similar process used with adoptive and non adoptive siblings
How are twin studies used
Monozygotic twins - identical twins - share 100% of genes
Dizygotic twins - share 50% of their genes
Comparing MZ twins reared apart and together
Comparing MZ and Dz twins
Results from behavioural genetics
Minnesota study of twins - MZ substantially more similar on all psychometric dimensions than DZ - didn’t matter if they were reared together or apart - Turkheimer 2000
Schizophrenia, mood disorders and anxiety - Plomin et al 2001, McGuffin et al 2019
Normal variations in personality and cognitive abilities - Loehlin 1992, Briley & Tucker-Drob 2017, Plomin & Defries 1998
Television watching, antisocial behaviour, social attitudes, loneliness, coffee drinking
Plomin genetics table

What are genome wide association studies - GWAS
Scans entire genome to find genetic variations associated with specific traits
Uses large datasets to identify genetic markers across the population
Genetic markers have been associated with risk factors for depression - Howard et al 2019
Genetic variants linked to academic success - Lee et al 2018