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pulmonary arteries
L and R branches of the pulmonary trunk that carry deoxygenated blood from the heart to each of the lungs
path of blood through the heart
RA via superior and inferior vena cava
RA to RV via tricuspid valve (R AV valve)
RV to pulmonary trunk and arteries via semilunar valve
pulmonary circuit to LA via pulmonary veins
LA to LV via bicuspid valve (mitral valve)
LV to Aorta via aortic valve
Aorta to everywhere except lungs
describe elastic arteries
Close to the heart
thick walls
larger than 10 mm
conducting arteries
describe muscular arteries
far from heart
.1-10 mm
thick tunica media
distributing arteries
describe fenestrated capillaries
Has some endothelial cells that contain pores (fenestrations), more permeable than continuous capillaries, function in absorption or filtrate formation, located in small intestines, endocrine glands, and kidneys
describe sinusoid capillaries
flat, intracellular gaps
incomplete basement
allows passage for large molecules
bone marrow, spleen, liver, adrenal glands
vasomotion
blood passing from arterioles to capillaries to venules by contraction and relaxation of precapillary sphincters
bulk flow
The movement of a fluid due to a difference in pressure between two locations.
active transport
the movement of ions or molecules across a cell membrane into a region of higher concentration, assisted by enzymes and requiring energy.
common iliac arteries
part of systemic circulation
stem off of aorta
sends blood to almost every organ of body
brachiocephalic artery
branches off into right subclavian and right common carotid
only on right side of body
coronary circulation
subclavian artery
supplies blood to upper limbs
breaks into internal thoracic, vertebral and thyrocervical
common carotid artery
divides into internal and external carotid arteries
L rises from aortic arch
what arteries provide blood to the brain?
internal carotid arteries and vertebral arteries
circle of willis
A circle of arteries at the base of the brain that supply blood to the brain
what veins combine to form the superior vena cava?
left and right brachiocephalic veins
which veins combine to form the inferior vena cava?
R and L common iliac veins
what branches does the arch of aorta have?
brachiocephalic, L subclavian and L common carotid
what artery supplies blood to the frontal lobe?
anterior cerebral artery
what artery supplies blood to the parietal and temporal lobes?
middle cerebral artery
internal jugular vein
primarily drains blood from the brain, receives the superficial facial vein, and empties into the subclavian vein
external jugular vein
Drains blood from the more superficial portions of the head, scalp, and cranial regions, and leads to the subclavian vein
external iliac vein
formed from femoral vein
drains legs
flows into common iliac vein
internal iliac vein
drains pelvic organs and integument
flows into common iliac vein
What are the beginning positions of the cardiac cycle?
A and V are in diastole
AV valves are open
semilunar valves are closed
What happens in atrial systole and diastole?
A contracts (P wave on ECG)
pressure rises and pumps blood to ventricles via AV valves
100 ms
what happens in ventricular systole phase 1?
Ventricles contract (QRS on ECG)
pressure rises but not enough to open valves
blood flows back to atria and closes AV valves
ventricles hold 130 mL before ejecting
What happens in ventriclular systole phase 2?
Ventricles contract
pressure rises enough this time to open semilunar valves
about 70-80 mL of blood is pumped out
what happens in ventricular diastole phase 1?
ventricles relax (T wave on ECG)
pressure drops and blood flows back into heart
semilunar valves close
no volume change
what happens in ventricular diastole phase 2?
pressure drops below atria
AV valves open to let blood flow from A to V
what makes the first heart sound?
closing of the AV valves in ventricle contraction
What are the 5 things that influence blood flow and pressure?
Cardiac output
Compliance
Volume of blood
Viscosity of blood
Blood vessel length and diameter
what is plasma composed of?
92% water, 7% proteins, the rest is all 1% (gases, minerals, carbs and lipids, waste products, vitamins, hormones and drugs)
describe red blood cells
1) contain hemoglobin
2) have no nucleus
3) biconcave structure
4) highly adapted
describe white blood cells
Leukocytes that contain nuclei and are the source of DNA in the blood sample
What are the steps of hemostasis?
1. vascular spasm (contraction of smooth muscle in blood vessel wall)
2. platelet plug formation (temporary seal against blood loss)
3. coagulation (blood clotting)
neutrophils
most abundant WBC granulocyte
multilobe nucleus
first defenders at inflammation site
have digestive chemical
arises from myeloid stem cells
eosinophils
enzymes that counteract histamine effect
phagocytize antigen-antibody complexes, pathogens and parasites
bi lobed granulocytes
basophils
bi/tri lobed nucleus granulocyte
have heparin, histamine and seratonin
related to allergiesw
lymphocytes
A type of white blood cell that make antibodies to fight off infections
agranulocyte
Monocytes
An agranular leukocyte that is able to migrate into tissues and transform into a macrophage.
Lymphocyte- NKC
attack tumor cells
lyphocyte-T cells
cell mediated adaptive immunity
lymphocyte- B cell
antibody mediated innate immune response
where is the endothelium?
tunica intima
type O blood
lacks A and B antigens
what does the sinoatrial node do in circulation of blood?
signals cause the V to contract and AV valves to close
what is afterload?
force the heart has to overcome to pump blood
In the first stage of hemostasis, the muscles in the blood vessel wall do what?
contract
In the second stage of hemostasis, which cells aggregate and form a plug?
platelets
In the third stage of hemostasis, the blood coagulates and forms a clot. The clotting is stimulated and regulated by clotting factors.
In addition to clotting enzymes, which substances are needed to control blood clots?
vitamin K and calcium ions
Red blood cells or erythropoietin cells arise from stems cells that are called
hemocytoblasts
how long does it take to become a mature erythrocyte? how long is their life span?
2 days
120 days
what is preload?
Degree of the stretch in ventricular muscle
Where does the respiratory zone start?
terminal bronchioles
what do type 1 alveolar cells do?
allow diffusion of CO2 and O2
what do type 2 alveolar cells do?
secrete pulmonary surfactant
What do alveolar macrophages do?
removes debris and pathogens
What does the trachea do?
transports mucus and inhaled particles out of the lungs
divides into 2 primary bronchi
how is the R primary bronchus different from the L?
It is more vertical, shorter and wider than L
What are the layers of the pleurae surrounding the lungs?
visceral (above)
parietal (connects to thoracic wall)
what are type one cells in the alveolar wall?
squamous epithelial cell
97% of alv surface area
highly permeable to gas
what are type 2 cells in the alveolar wall?
interspersed in type 1
secrete pulmonary surfactant
what are alveolar machrophages in the alveolar wall?
phagocytic cell of immune system
removes debris and pathogens
what muscles are used with a forced inhalation?
scalenes, traps, diaphragm and external intercostal muscles
What muscles are used with forced exhalation?
abs, internal intercostal, diaphragm and external intercostal muscles
where are the frontal sinuses?
center of eyebrows
Where are the maxillary sinuses?
cheek bones, under eyes
sinus infection hub
Where are the sphenoid sinuses?
between eyes, nose bridge
nasopharynx
region of the pharynx at the back of the nose and above the soft palate
oropharynx
the area directly posterior to the mouth
passage for air and food
2 sets of tonsils
laryngopharynx
region of the pharynx below the epiglottis that includes the larynx
route for ingested material and air
larynx
voice box; passageway for air moving from pharynx to trachea; contains vocal cords
regulates volume of air that enters and leaves lungs
Epiglottis
a flap of cartilage at the root of the tongue, which is depressed during swallowing to cover the opening of the windpipe.
Trachea
a large membranous tube reinforced by rings of cartilage, extending from the larynx to the bronchial tubes and conveying air to and from the lungs; the windpipe.
what is the order of structures through which air will flow as it enters the lungs?
Tertiary bronchi, terminal bronchioles, respiratory bronchioles, alveolar ducts
what are the 3 factors for easy breathing?
surface tension of the alveolar fluid
lung compliance
airway resistance
Which factor is responsible for the difference in pitches of the sound produced by the vocal cords?
Tightening and slacking of the membranous folds
What affects hemoglobins affinity for O2
high PCO2
high PO2
increase in temperature
low tissue pH
carbaminohemoglobin transport
How is gas affected by pressure?
moves from high to low pressure
what happens during inhalation?
thoracic cavity expands
external intercostal muscles contract
diaphragm contracts
what happens during exhalation
thoracic cavity reduces
external intercostal muscles and diaphragm relaxes
Which part of the brain signals the respiratory center to increase respiration during times of stress?
limbic system
Which part of your brain allows you to have voluntary control over your breathing in order to hold your breath underwater?
cerebral cortex
What produces hydrochloric acid?
parietal cells of the stomach
HCI activates pepsin and kills bacteria
what produces intrinsic factor?
Parietal cells of the stomach
IF absorbs vitamin B12 in small intestine
What do chief cells secrete?
pepsinogen
where is gastrin produced and what is it's purpose?
in stomach mucosa in G cells
promotes gastric emptying and intestinal muscle contraction
relaxes ileocecal valve and triggers mass movements in large intestine
where is ghrelin produces and what does it do?
in stomach mucosa
regulates food intake
where is histamine produced and what does it do?
stomach mucosa
stimulates parietal cells to release HCI
where is serotonin produced and what does it do?
gastric mucosa
contracts stomach muscle
where is somatostatin produced and what does it do?
stomach mucosa in D cells
restricts gastric and pancreatic secretions
reduces intestinal absorption in small intestine
what cells secrete insulin and glucagon
Islets of Langerhans
where is lingual lipase produced and what does it break down?
lingual glands
triglycerides into free fatty acids
where is salivary amylase produced and what does it break down?
salivary glands
polysaccharides into oligo and disaccharides
where is a-dextrinase produced and what does it break down?
small intestine
a-dextrin into glucose
where is enteropoptidase produced and what does it break down?
small intestine
trypsinogen into trypsin
where is lactase produced and what does it break down?
small intestine
lactose into glucose and galactose
where is maltase produced and what does it break down?
small intestine
maltose into glucose
where is sucrase produced and what does it break down?
small intestine
sucrose into fructose and glucose