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The skeletal system consists of _________, cartilage, ligaments, and other connective tissues.
bones
Bones serve as levers for movement through _________ action.
muscle
Hematopoiesis is the production of _________ cells inside bones.
blood
The axial skeleton consists of _________ bones.
80
The appendicular skeleton consists of _________ bones, including those of the limbs and girdles.
126
Hyaline cartilage is the most _________ type of cartilage found in the skeletal system.
abundant
Fibrocartilage provides great _________ strength to resist compression.
tensile
Compact bone appears _________ and solid.
smooth
Spongy bone is composed of a network called _________ that provides structural support.
trabeculae
The epiphyseal plate is responsible for _________ growth in long bones.
lengthwise
Osteoblasts are responsible for producing the _________ matrix.
bony
Osteocytes maintain bone matrix and act as _________ sensors.
stress
Osteoclasts remove and _________ bone during remodeling.
remodel
The periosteum is a double-layered _________ covering the external surfaces of bones.
membrane
The endosteum is a delicate connective tissue membrane covering the _________ bone surface.
internal
Calcium phosphate is an important _________ component of bone tissue.
inorganic
Bone matrix is chemically digested by _________ enzymes from lysosomes.
proteolytic
Endochondral ossification involves replacing _________ cartilage with bone.
hyaline
During bone development, mesenchymal cells transition to become __________.
osteoblasts
The growth plate consists of five zones, including resting, proliferation, _________, calcification, and ossification zones.
hypertrophic
Appositional growth allows bones to grow in _________.
width
Hormones like growth hormone and _________ hormone regulate bone growth.
thyroid
High blood calcium levels prompt the secretion of _________ from the thyroid gland.
calcitonin
Excess PTH stimulates _________ to resorb bone and release calcium into the bloodstream.
osteoclasts
The _________ center is where bone begins to form in endochondral ossification.
primary ossification
Bone remodeling units consist of osteoblasts and osteoclasts coordinating their _________.
activities
Fractures from trauma are most common in _________ age groups.
youth
A stress fracture is a thin break caused by increased physical _________.
activity
A simple fracture is defined as a broken bone that does not _________ the skin.
penetrate
In bony callus formation, _________ produce new trabeculae in cartilage.
osteoblasts
The first stage of fracture repair is called _________ formation, involving blood clotting.
hematoma
During the fibrocartilaginous callus formation, _________ cells help clear debris.
phagocytic
The epiphyseal line is the remnant of the _________ plate after growth has ceased.
epiphyseal
Calcium levels are tightly regulated by hormones because they play roles in nerve _________ and muscle contraction.
transmission
Hypocalcemia leads to _________ in neuromuscular excitability.
hyperexcitability
The primary ossification center is typically located in the __________ of long bones.
center of diaphysis
Bone growth in width is referred to as _________ growth.
appositional
Mechanical stress can stimulate _________ by signaling osteocytes to increase activity.
bone deposition
Reducing calcium in the diet requires an increased intake of _________ for absorption.
vitamin D
Osteogenic cells can become osteoblasts or remain as _________ cells in the periosteum and endosteum.
stem
The central canal of an osteon contains _________ and nerve fibers.
blood vessels
Calcification in bone development primarily occurs due to _________ binding to collagen.
calcium phosphate
In the ossification zone, chondrocytes deteriorate to leave behind _________ cartilage.
calcified
Osteocytes communicate information about bone stress through _________ connected by canaliculi.
cell projections
The transition from fetal hyaline cartilage to bone tissue requires the _________ of cartilage.
breakdown
During bone remodeling, osteoclasts phagocytize the ________ matrix.
dead osteocyte
Spongy bone is characterized by the absence of _________; instead, it has trabeculae.
osteons
Calcitonin lowers blood calcium levels by inhibiting _________.
osteoclasts
Bone healing stages include hematoma formation, callus formation, and __________ formation.
bony callus
Osteoblasts secrete a substance called _________, which is unmineralized bone matrix.
osteoid
Bony remodeling helps to repair existing bone and _________ the structure.
maintain
The process where necrotic or damaged tissues are cleared up in a fracture is termed _________.
phagocytosis
Callus formation occurs in the fracture repair process during the _________ process.
fibrocartilaginous
The osteon (Haversian system) is the structural unit of _________ bone.
compact
Collagen fibers arranged in different directions in lamellae help compact bone resist _________.
twisting
Sustained hypercalcemia can lead to deposits of calcium salts in _________ or kidneys, resulting in complications.
blood vessels
Mineralization of bone matrix mainly occurs through the action of _________ cells.
osteoblasts
Bone is made of both organic components including osteoid and _________ components like calcium phosphate.
inorganic
The periosteum contains sharp __________ fibers that anchor blood vessels and nerves to the bone matrix.
Sharpey's
The _________ zone of the epiphyseal plate is where chondrocytes are actively dividing.
proliferation
The ossification center forms within the _________ and starts laying down bone.
fibrous membrane
Stress fractures typically occur due to overuse and _________.
repeated impact
Calcium metabolism is crucial for normal function of the cardiovascular and _________ systems.
muscular
Resting cartilage zone contains chondrocytes that are relatively _________.
inactive
Fractures caused by disease are termed _________ fractures.
pathologic
During chondrocyte hypertrophy, the size of lacunae _________.
increases
The _________ cell type in the bone is responsible for maintaining mineral homeostasis.
osteocyte
Chondrocytes dying in the calcification zone lead to bone _________.
formation
Direction of collagen fibers impacts the bone’s resistance to _________.
stress
Resorption bays are depressions where osteoclasts carry out bone _________.
resorption
Transitional processes in the ossification sequence lead to the replacement of cartilage with _________.
bone tissue
Long bones will only grow longer until _________ plate closure occurs.
epiphyseal
Phagocytosis occurs in the fracture repair to clear out _________ tissue.
necrotic
Osteocytes help regulate bone activity through signals affecting _________ and osteoclasts.
osteoblasts
Bone growth and remodeling are influenced by __________ factors like exercise and nutrition.
environmental
In summary, bone is a dynamic organ, constantly undergoing a process known as _________.
remodeling