[PCOL-FIN-02-PT1] ANTIDEPRESSANTS

THIS FLASHCARDS IS ABOUT [PCOL] ANTIDEPRESSANTS.

Antidepressants

These drugs are for mood disorders or depression.

Depression

This is the long period of sadness, guilt, decreased interest in normal activities due to life situation.

Info

Sometimes, depression occurs alone but it can also be part of larger disorder, turning in to mania or bipolar disorder.

Info

Bipolar disorder happens in months not just within a day. For example, you’re sad today but after 4-6 months you are now happy.

1. Serotonin (5-HT)

2. Norepinephrine

Depression is due to the deficiency of (1)___ and (2)_____ in the brain; has something to do with the monoamine hypothesis.

Antidepressants

These drugs general MOA enhances the levels of serotonin (5-HT) or norepinephrine.

• Selective serotonin reuptake inhibitors (SSRIs)

• Serotonin-norepinephrine reuptake inhibitors (SNRIs)

• Tricyclic antidepressants (TCAs)

• Monoamine oxidase inhibitors (MAOIs)

• Atypical antidepressants

What are the (5) Classes of Antidepressants?

Hint: SST-MA

Info

These (4) classes of antidepressants are typical.

• Selective serotonin reuptake inhibitors (SSRIs)

• Serotonin-norepinephrine reuptake inhibitors (SNRIs)

• Tricyclic antidepressants (TCAs)

• Monoamine oxidase inhibitors (MAOIs)

Info

Typical antidepressants increases serotonin and norepinephrine levels.

Info

Atypical antidepressants produces additional effects.

• Synthesis

• Storage

• Release

What is the (3) Functions of Pre-Synapse?

Hint: SSR

Tryptophan

What is the precursor in the serotonergic neurotransmission?

Serotonin (5-HT)

Tryptophan synthesizes what neurotransmitter?

Vesicles

Serotonin (5-HT) are stored in?

1. Cleft

2. Post-synapse serotonergic receptors

After depolarization, serotonin (5-HT) will be released to the (1)____ and will bind to the (2)____ serotonergic receptors.

Norepinephrine

What is the principal neurotransmitter?

Tyrosine

What is the precursor in the noradrenergic neurotransmission?

Dopamine

Tyrosine will be synthesized into?

Dopamine-b-hydroxylase

The dopamine will be stored in the vesicle and is synthesized by _______________ to norepinephrine.

Info

What is the fate of serotonin and norepinephrine?

• Once available in the cleft, they will bind to the post-synaptic receptors (serotonergic and adrenergic) enhancing the neurotransmission.

• There is termination of neurotransmitter (decreased transport of impulses).

• Diffusion towards systemic circulation

• Metabolism via MAO

• Reuptake via SERT & NET

What are the (3) Mechanisms for Termination of Neurotransmitters?

Reuptake

What is the major termination of serotonin and norepinephrine once available in the cleft?

Info

If the concentration of neurotransmitter is low, the response is also low.