UAMS- HEMATOLOGY PRACTICAL 2 (LABS 12-17)

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38 Terms

1
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What might be an indication for a 200 or 300 WBC differential?

When the WBC count is increased or decreased and abnormal or immature cells are seen.

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1. band

2. seg

<p></p><p></p>
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myeloblast

<p></p>
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4. seg

5. metamyelocyte

<p></p>
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6. myelocyte

7. band

<p></p>
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blast

<p></p>
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9. promyelocyte

10. metamyelocyte

<p></p>
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11. promyelocyte

<p></p>
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12. myelocyte

<p></p>
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blast

<p></p>
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metamyelocyte

promyelocyte

<p></p>
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myelocyte

<p></p>
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what are the cells in the picture?

<p></p>
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blast

<p></p>
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promyelocyte

segmented neutrophil

<p></p>
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promyelocyte

myelocyte

<p></p>
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The presence of 5 or more lobes in a neutrophil

hypersegmentation

is seen in megaloblastic anemias

<p>hypersegmentation</p><p>is seen in megaloblastic anemias</p>
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larger dark granules that can be present with bacterial infections, burns, yeast infections, and pregnancy

toxic granulation

<p>toxic granulation</p>
19
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Blue cytoplasmic inclusions that can be present with bacterial infections, burns, yeast infection, and pregnancy

dohle bodies

<p>dohle bodies</p>
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most cells have 1 or 2 lobes ( bi lobed nuclei)

Pegler-Huet disorder

<p>Pegler-Huet disorder</p>
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Smooth homogenous inclusion in neutrophil

LE cells

<p>LE cells</p>
22
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Large grey-green granules

Chediak-higashi disease

<p>Chediak-higashi disease</p>
23
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In Chediak-Higashi disease, abnormal fustion of granules in most cells containing granules what types of cells are these?

granulocytes, monocytes, lymphcytes

24
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Dohle Body-like inclusions in neutrophils, eosinophils, basophils, and monocytes.

May-Hegglin

<p>May-Hegglin</p>
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The dohle body like inclusion in May-Hegglin are composed of what?

precipitate myosin heavy chains

26
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May -Hegglin is associated with————— and —————-

dohle-like inclusions and giant platelets

27
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intracellular yeast

<p></p>
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intracellular bacteria

<p></p>
29
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What conditions/anomaly/disease could possibly be seen with hypersegmentation?

megaloblastic anemia

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What conditions/anomaly/disease could possibly be seen with toxic granulation, dohle bodies, and vaculoization?

pregnancy, burns, bacterial infections, and yeast infections

31
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What conditions/anomaly/disease could possibly be seen with myeloid malignancies?

bilobed nuceli

32
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What conditions/anomaly/disease could possibly be seen with giant platelets and dohle bodies?

may-hegglin anomaly

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What conditions/anomaly/disease could possibly be seen with phagocytized cell nucleus?

systemic lupus erythematosus

34
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depending on the manufacturer the granules in Leukocyte Alkaline Phosphatase (LAP) stain will be?

blue or red

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What is a normal LAP value?

40-170

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The principles diagnostic use of the LAP stain is?

to help differentiate a leukemoid reaction from a chronic myelocytic leukemia (CML)

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Conditions that will give an elevated LAP score are?

leukemoid rxn, pregnancy, and polycythemia vera

38
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Key features of CML?

decreased LAP; +Ph