Hereditary RBC Membrane Defects

Identify the RBC membrane defect:

• defects in protein(s) that disturbs vertical membrane

HS

Identify the RBC membrane defect:

• MCHC value reaches 38 g/dL

HS

Identify the RBC membrane defect:

• defect in Protein 4.1

HE

Identify the RBC membrane defect:

• defects in proteins that disrupt the horizontal linkages

HE

Identify the RBC membrane defect:

• rare subtype of hereditary elliptocytosis

• severe defect in spectrin

HP

Identify the RBC membrane defect:

• defect in Band 3; causes increased membrane rigidity

• resistant to malaria

SEA Ovalocytosis

Identify the RBC membrane defect:

• Rh-associated protein (RHAG)

• increased membrane permeability to Na and K

Overhydrated hereditary stomatoytosis

Identify the RBC membrane defect:

• most common form of stomatocytosis

Dehydrated hereditary stomatocytosis; Hereditary xerocytosis

Identify the RBC membrane defect:

• Piezo-type mechanosensitive ion channel component 1

Dehydrated hereditary stomatoytosis; Hereditary xerocytosis

Identify the RBC membrane condition:

• defect in Protein 4.2

• Ankyrin problem

• alpha and beta spectrin problem

HS

HS stands for _

Hereditary spherocytosis

Identify the RBC membrane condition:

• MCHC reaches 35-38

HS

Only autosomal recessive RBC membrane defect condition

HP

HP stands for _

Hereditary pyropoikilocytosis

This is a rare subtype of HE (Hereditary elliptocytosis)

HP

Identify the RBC membrane condition:

• Protein 4.1 defect

HE

Identify the RBC membrane condition:

• Horizontal linkage disruption

• Protein 4.1

HE

Identify the RBC membrane condition:

• Band 3 defect

SEA Ovalocytosis

Other name of Hereditary ovalocytosis

SEA Ovalocytosis

Identify the RBC membrane condition:

• associated with Rh-associated protein (RHAG)

Overhydrated hereditary stomatocytosis