Hereditary RBC Membrane Defects

Identify the RBC membrane defect:

• defects in protein(s) that disturbs vertical membrane

Hereditary spherocytosis

Identify the RBC membrane defect:

• MCHC value reaches 38 g/dL

Hereditary spherocytosis

Identify the RBC membrane defect:

• defect in Protein 4.1

Hereditary elliptocytosis

Identify the RBC membrane defect:

• defects in proteins that disrupt the horizontal linkages

Hereditary elliptocytosis

Identify the RBC membrane defect:

• rare subtype of hereditary elliptocytosis

• severe defect in spectrin

Hereditary pyropoikilocytosis

Identify the RBC membrane defect:

• defect in Band 3; causes increased membrane rigidity

• resistant to malaria

SEA ovalocytosis; Hereditary ovalocytosis

Identify the RBC membrane defect:

• Rh-associated protein (RHAG)

• increased membrane permeability to Na and K

Overhydrated hereditary stomatoytosis

Identify the RBC membrane defect:

• most common form of stomatocytosis

Dehydrated hereditary stomatocytosis; Hereditary xerocytosis

Identify the RBC membrane defect:

• Piezo-type mechanosensitive ion channel component 1

Dehydrated hereditary stomatoytosis; Hereditary xerocytosis