antigen antibody immunoglobulins

What are under Antigen?

immunogen

epitope

○ Serves as a marker for the immune system in identifying whether if harmful or not

○ Found in bacteria, viruses, tumors, cells

○ Serves as a receptor interacting with an antibod

○ May or may NOT have immunogenicity

○ Recognized by the antibody or T cells

ANTIGEN

○ Serves as a marker for the immune system in identifying whether if harmful or not

ANTIGEN

○ Found in bacteria, viruses, tumors, cells

ANTIGEN

○ Serves as a receptor interacting with an antibod

ANTIGEN

○ May or may NOT have immunogenicity

ANTIGEN

○ Recognized by the antibody or T cells

ANTIGEN

foreign substance that induces an immune response when bound to an antigen receptor

IMMUNOGEN –

immunologically active site of an antigen that binds with an antibody

○ EPITOPE –

• Produced by B cells

• 2 identical light chain

  • Where the epitopes are located

• 4-5 heavy chains

  • Determines the type of antibody (IMMUNIOGLOBULINS)

  • IgA, IgG, IgM, IgE, IgD

ANTIBODY

○ Produced by B cells

ANTIBODY

Where the epitopes are located

• 2 identical light chain

Determines the type of antibody (IMMUNIOGLOBULINS)

○ IgA, IgG, IgM, IgE, IgD

• 4-5 heavy chains

● Directly attacks the antigen, destroying and neutralizing them

● Activate the complement system

● Activate anaphylaxis by releasing histamine

● Stimulates the Antibody mediated hypersensitivity

IMMUNOGLOBULIN (Major Functions)

● Directly attacks the antigen, destroying and neutralizing them

IMMUNOGLOBULIN (Major Functions)

● Activate the complement system

IMMUNOGLOBULIN (Major Functions)

● Activate anaphylaxis by releasing histamine

IMMUNOGLOBULIN (Major Functions)

● Stimulates the Antibody mediated hypersensitivity

IMMUNOGLOBULIN (Major Functions)

● Antibody produced by and expressed on the surface of B cells

● Predominates in initial immune response

● Most efficient in activating the complement pathway

● Localized in the intravascular compartment

IgM

● Antibody produced by and expressed on the surface of B cells

IgM

● Predominates in initial immune response

IgM

● Most efficient in activating the complement pathway

IgM

● Localized in the intravascular compartment

IgM

● Major antibacterial and antiviral antibody in the blood

● Carried by the plasma into the tissues

● Major Ig synthesized during a secondary immune response

● Confers to long immunity

● Can cross placenta that provides passive protection to newborns

IgG

● Major antibacterial and antiviral antibody in the blood

IgG

● Carried by the plasma into the tissues

IgG

● Major Ig synthesized during a secondary immune response

IgG

● Confers to long immunity

IgG

● Can cross placenta that provides passive protection to newborns

IgG

● Found in serum and secretions

● Predominant immunoglobulin on mucous membrane surface

● Saliva, breastmilk, urine, GIT, GUT

● Defends external body surfaces

IgA

● Found in serum and secretions

IgA

● Predominant immunoglobulin on mucous membrane surface

IgA

● Saliva, breastmilk, urine, GIT, GUT

IgA

● Defends external body surfaces

IgA

● Present in blood at low levels

● Bound to high affinity receptor on mast cells and basophils

● Serves as primary factor in eliminating helminthic parasitic infection

IgE

● Present in blood at low levels

IgE

● Bound to high affinity receptor on mast cells and basophils

IgE

● Serves as primary factor in eliminating helminthic parasitic infection

IgE

● Present in blood at low level

● Primary function is to serve as an antigen receptor on mature B cells

IgD

● Present in blood at low level

IgD

● Primary function is to serve as an antigen receptor on mature B cells

IgD