Gen Physio - Transcription Factors

TFIID + TBP

Binds to the TATA box, a DNA sequence in the promoter region, and helps position RNA polymerase on the gene.

TFIIB

Helps stabilize the interaction between TFIID and RNA polymerase, and it is also involved in recruiting other transcription factors.

TFIIE

Helps recruit and regulate TFIH.

TFIIF

Stabilizes the interaction between RNA polymerase and TBP and TFIIB, and it also helps recruit TFIE and TFIIH.

TFIIH

Unwinds the DNA at the transcription start site and phosphorylates the RNA polymerase, which is required for the polymerase to release from the promoter and initiate transcription.

TFIIA

Helps recruit TFIIB.

TP53

Tumor suppressor transcription factor. Preventing cancer

NF-kb (Nuclear Factor kappa-light-chain-enhancer of activated B cells)

Regulates immune response, inflammation, and cell survival.

FOXP2

Involved in speech and language development. (Linked to speech and language disorders.)

Mad (MXD family)

Competes with Myc. While Myc activates transcription, Mad represses it by recruiting Sin3/HDAC complexes.

(Cell cycle control and differentiation.)

Engrailed (EN1/EN2)

Repressor during early development, especially in the brain.

Gfi1

Repressor in hematopoietic cells. (Blood cell differentiation and immune function.)

ZEB1 and ZEB2

Repress epithelial genes like E-cadherin. (EMT, development, cancer progression.)

MYC

Promotes cell growth and proliferation. (Frequently seen in cancers, overexpression.)