p53 mediated repair OR Apoptosis

FINAL EXAM

catalytic monomer in a caspase's active site that cuts peptide bonds

cysteine

directed by binding to p21 to load DNA polymerase delta at sites of DNA repair

PCNA

produces the granules of enveloped nuclear DNA of the stratum granulosum which are a hallmark of apoptosis

CAD

cuts procaspase-3 to produce active caspase-3

caspase-9

reduced in expression within keratinocytes to produce the stratum granulosum composed of apoptotic cells

Bcl2

Leaks through Bax-ringed holes into the cytoplasm to help form the apoptosome with Apaf-1 to mature casapase-9

Cytochrome C

protein whose gene has weak p53 response elements upstream from the TATA box

p21

enzymatic activity exerted by CBP on the N-terminal tail lysines of nucleosomal histones

acetylase

the lysines of the N-terminal extensions of the histones within a nucleosome interact specifically with the _____s of DNA wrapped around adjacent nucleosomes

phosphate

domain of CBP that binds to acetylated lysines on histone' N-terminal extensions ("tails")

Bromo

monomer within the sequence of target proteins that allows substrate recognition by caspases

aspartate

domain of CBP that binds to phosphorylated transcription factors

Kix

protein whose gene has strong p53 response elements upstream from the TATA box

p21

forms an inhibitory heterodimeric complex with Bax to prevent apoptosis

Bcl2

in excess, forms large "holes" (permeability pores) in the mitochondrial outer membrane sufficient to leak proteins into the cytoplasm from the intermembrane space

Bax

cut by caspase 3 to activate cleavage of nuclear DNA

ICAD