Mucosal epithelial cells and TLRs
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How do mucosal epithelial cells recognize pathogens?
Through Toll-like receptors (TLRs).
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What happens after TLRs recognize a pathogen?
A signaling cascade activates the NFκB transcription factor.
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What do mucosal epithelial cells produce after TLR activation?
Inflammatory cytokines (IL-1 and IL-6), antimicrobial peptides, and chemokines.
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What is the role of chemokines in immune response?
They recruit neutrophils, eosinophils, dendritic cells, and T cells.
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How do mucosal epithelial cells control the inflammatory response?
Through a high turnover rate, preventing damage from excessive inflammation.
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