BMS - Lecture 6 : Molecular motors, proteins in cell organisation and movement

movements of living things: organisms

muscle contraction

movements of living things: cells

pseudopodia

movements of living things: organelles & macromolecules in cells

cell division

2 key proteins of skeletal muscle

actin

myosin

what are fascicles

bundles of muscle fibres

whats a sarcomere

centre of contraction

what kind of cells do muscle fibres have

long

multinucleated

myofibrils consist of what type of filaments 2

thick

thin

myofibrils are surrounded by —— vesicles containing —- = —- —-

flattened

Ca2+

sarcoplasmic reticulum

myofibrils consist of what 2 bands

i band

A band

I band contains —- filaments of —-

thin

actin

A band contains —- filaments of —-

thick

myosin

tropomyosin & troponin are in —- filaments

thin

what structure is this

myosin

what structure is this

what is the name of the circled part

myosin

heavy chain

what structure is this

what is the name of the circled part

myosin

light chain

how many polypeptides does myosin tail consist on

6

each moysin head functions as a —- & as —- binding site

ATPase

ATP

what structure is this

G-actin

how many protein domains does G-actin have

4

What is F-actin

fibrous polymer of actin

what is a dimer

linkage of 1 alpha-helices

how many subunits does troponin have

name them

3

troponin C

troponin I

troponin T

what does troponin I do 2

binds actin

prevents binding of myosin head

what does troponin C do

Binds Ca2+

what does troponin T do

binds tropomyosin

what structure is this

tropomyosin-troponin complex

what triggers muscle contraction

Ca2+

what is the most abundant cytosolic protein

actin

what are muscle stem cells called

satellite cells

what are satellite cells involved in

Muscle repair and regeneration

Maintenance of muscle tissue

Contribution to muscle growth and adaptation

what is one different between smooth muscle and skeletal muscle? hint. something to do with troponin C

calmodulin