Unit 6 DNA -->RNA--->Protein (LT1-3)

Griffith

what scientist discovered that two strains of bacterium was pathogenic and one harmless?

pathogenic

there are to types of bacterium one harmless and one _________

griffith

what scientist mixed heat-killed remains of the pathogenic strain with living cells of the harmless strain, some living cells pathogenic?

transformation

change in genotype and phenotype due to assimilation of foreign DNA

Hershey and Chase

what scientists designed an experiment showing that only one of the components of bacteriophage (DNA or Protein) enters an E.Coli cell during infection?

Genetic info

Hershey and Chase conconlcued that the injected DNA of the phage provides the __________

Watson and Crick

what scientists built a three dimensional model of DNA as a double helix?

middle

Watson and Crick discovered that a sugar phosphate backbone are on the sides and the bases are in the ________

Rosalind Frankiln

what scientist produced an X-ray Crystallography of DNA?

Chargaff

what scientist created the base -pair rule?

1. each base has to e complementary

ex. A-T & C-G

What are Chargaff’s rules?

antiparallel

DNA runs _______

purines (big)

Guanine and Adenine are the _________

* double ring structures

pyrimidines (small)

cytosine and thymine are the _________

* single ring helix structure

nitrogen containing bases

the bases are all _________

semiconservative

DNA replication is __________

s phase

DNA replication occurs in the _______

topisomerase

corrects over-winding in the DNA fork

helicase

untwists DNA helix

SSBP

stabilizes the double helix

primase

RNA primer

DNA polymerase lll

adds DNA nucleotides

DNA polymerase l

removes DNA

ligase

“glue” fragments all together

leading strand

new complementary DNA strand synthesized continouslu along the templete going 5’3’ direction

lagging strand

discontinously synthesized DNA strand that elongates by means of __**okazaki fragments**__