Drug-drug interactions; Drug-disease interactions

ACE-inhibitors + NSAIDs

Hyperkalaemia, decline in renal function

Ciprofloxacin + olanzapine

Ciprofloxacin inhibitis CYP1A2. As a result the plasma-concentration of olanzapine increases

Digoxin + furosemide

Hypokalaemia may increase risk for digitalis-intoxication

Nitroglycerin + sildenafil

Increased risk of severe hypotension

Spironolactone + potassium chloride

Hyperkalaemia

Verapimil + atenolol

Bradycardia and hypotension

Warfarin + acetylsalicylic acid

Increased risk of bleeding

Anticholinergic drugs: disease, potential outcome

Disease: Dementia

Potential outcome: Delirium

Antipsychotics: disease, potential outcome

Disease: Parkinson’s disease

Potential outcome: Worsening of parkinson’s disease symptoms

Aspirin: disease, potential outcome

Disease: Peptic ulcer disease

Potential outcome: Gastrointestinal bleeding

First-gen CCB: disease, potential outcome

Disease: Congestive heart failure

Potential outcome: Worsening of heart failure

NSAIDs: disease, potential outcome

Disease: Decreased renal function

Potential outcome: Renal failure

NSAIDs: disease, potential outcome

Disease: Heart failure

Potential outcome: Worsening of heart failure

Thiazides: disease, potential outcome

Disease: Gout

Potential outcome: Worsening of gout

Tricyclic antidepressants: disease, potential outcome

Disease: Epilepsy

Potential outcome: Lower seizure threshold (more so if toxic levels of tricyclic anti-depressant)