Studied by 4 people
Parkinson's disease
________ is caused by the loss of dopamine-producing cells of the substantia nigra pars compacta in the midbrain.
Huntington's Disease
Diagnosis of ________ is made by a detailed clinical exam and examining the family history.
HD doesnt
________ allow the individual to walk, think, talk, and reason.
Death
________ is usually caused by respiratory failure or pneumonia.
Amyloid Precursor Protein
The gene encoding the ________ (APP) is on Chromosome 21.
Reductions
________ occur in the markers for many neurotransmitters that allow cells to communicate with others.
Early-onset Alzheimers
________ is related to mutations in the genes for presenilin 1 and 2.
Huntington's Disease
The mutation for ________ is an expanded triplet repeat.
radioactive chemical marker
A mildly ________ can show amyloid plaques and tau tangles in living people.
Pallidotomy
________: surgical deactivation or destruction of overactive structures that greatly reduces symptoms.
Genes
________ for Early- onset Alzheimers causes the beta- amyloid plaques to accumulate earlier.
MPTP
________ is converted to a substance in the brain that destroys dopamine- producing neurons.
Presenilin
________ 1 and 2 are proteins involved in the process of generating beta- amyloid from APP.
Apolipoprotein E
________ (ApoE): influences ones susceptibility to Alzheimers disease later in life.
Levodopa
________: a drug discovered in the 1960s that is converted to dopamine in the brain.
Amyotrophic Lateral Sclerosis
________ affects neurons that control voluntary muscle movements.
Neurofibrillary tangles
________: a modified, aggregated form of the protein tau in the cell bodies of neurons.
neural systems
The damage to ________ for attention, memory, learning, and higher cognitive abilities are believed to cause clinical symptoms.
Beta amyloid
________: a small fibrillar peptide that accumulates in the spaces around synapses in Alzheimers patients.
Mice
________ carrying mutant genes develop abnormalities and some of the microscopic changes in tissue structure that occur in humans.
Gene transfer of trophic factors
________ is being studied in animal models and tested in clinical trials.
Alpha secretases
________: break up beta- amyloid peptides and prevent amyloid accumulation.
Beta
________ and gamma secretases: enzymes that cut the amyloid peptide and release it from neurons into the space around synapses.
Carbidopa
________ helps prevent the breakdown of levodopa in the bloodstream.
Predictive testing
________ is only for adults.
signs of progressive paralysis
The first ________ are seen in the hands and feet or in muscles of speech and swallowing.
Neuritic plaques
________ and neurofibrillary tangles form in brain regions important for memory and intellectual function.
brain tissue
The ________ is usually obtained through an autopsy.
form of ApoE
The epsilon 4 ________ is most clearly associated with increased risk for Alzheimers disease.
HD
________ may be caused by the gain of a new and toxic function among these proteins.
Amyotrophic Lateral Sclerosis
________ is also called Lou Gehrigs disease.
Death
________ can occur by pneumonia, heart failure, or other complications.
MPTP
________ (1- methyl- 4- phenyl- 1, 2, 3, 6 tetrahydropyridine) was accidentally discovered by drug synthesizers in the late 1970s.
Early onset Alzheimers
________: a rare, dominantly inherited disorder that causes the onset of Alzheimers in an individuals 40s or 50s instead of past 65.
Beta-amyloid
A small fibrillar peptide that accumulates in the spaces around synapses in Alzheimer's patients.
Neurofibrillary tangles
A modified, aggregated form of the protein tau in the cell bodies of neurons.
Early-onset Alzheimer's Disease
A rare, dominantly inherited disorder that causes the onset of Alzheimer's in an individual's 40s or 50s instead of past 65.
Apolipoprotein E (ApoE)
A protein that influences one's susceptibility to Alzheimer's disease later in life.
Beta and gamma secretases
Enzymes that cut the amyloid peptide and release it from neurons into the space around synapses.
Alpha secretases
Enzymes that break up beta-amyloid peptides and prevent amyloid accumulation.
Levodopa
A drug discovered in the 1960s that is converted to dopamine in the brain.
Pallidotomy
The surgical deactivation or destruction of overactive structures that greatly reduces symptoms of Parkinson's Disease.
Note 
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