What are the two tracers that are primarily used in lymphatics?
Tc99m Tilmanocept (Lymphoseek)
Tc99m Sulfur Colloid
What tracer is more commonly used?
Tc99m Tilmanocept
1/22
Looks like no tags are added yet.
Name | Mastery | Learn | Test | Matching | Spaced |
---|
No study sessions yet.
What are the two tracers that are primarily used in lymphatics?
Tc99m Tilmanocept (Lymphoseek)
Tc99m Sulfur Colloid
What tracer is more commonly used?
Tc99m Tilmanocept
What is the form of the Tc99m Sulfur Colloid
particles
Where does the sulfur colloid get taken up? (MOL)
phagocytosis
What molecules are used with tilmanocept?
Mannose molecules
What size are the molecules for tilmanocept?
about 7 nanometers
Where does the tilmanocept bind?
receptor protein called CD-206
Where is the CD-206 found?
macrophages
dendritic cells
what is telmanocept diluted with?
sodium chloride
Does localization of tilmanocept occur fast or slow?
fast
how long can the tilmanocept remain in the lymph nodes?
30 hours
Sulfur Colloid Particle size
ranges from 0.1-1 microm, mean size of 3 microm
Indications for sulfur colloid use:
sentinel node localization
lymphoscintigraphy - evaluate for lymphedema
lymphatic leak
Filter that can be applied for sulfur colloid
0.1 or 0.2 micron filter to eliminate larger particles
What is in a sulfur colloid kit?`
sodium thiosulfate anhydrous
edetate disodium
bovine gelatin
What is is Vial A for sulfor colloid kit?
hydrochloric acid solution
What is in Vial B for a sulfur colloid kit?
aqueous solution of sodium biphosphate anhydrous
sodium hydroxide
The preparation steps for a sulfur colloid kit:
maximum of 500mCi in 1-3 mL of sodium pertechnetate added to kit
add 1.5 mL of Vial A to kit
Place kit in boiling water bath to fully cover liquid in the vial - boil for 5 minutes
cool for 3 minutes
add 1.5 mL of vial B to the kit
BUD: 6 hours
After reconstruction it can be filtered
what is the BUD for sulfur colloid?
6 hours
Lymphoseek
Tc99m Tilmanocept
How quick does localization occur with Lymphoseek
within 10 minutes
recommended dose of lymphoseek
0.5 mCi