Musculoskeletal System Drugs/Medications

Bisphosphonates-Alen “dronate” (Fosamax)

• Mode of action​

  • Decrease osteoclastic activity, which decreases bone resorption​ for osteoporosis

• Side effects​

  • Esophageal ulceration ​

  • Headache, nausea, diarrhea, dyspepsia​

• Clinical Pearls​

  • Taken with full glass of water and must remain upright for 30 min

  • Taken on an empty stomach ​

  • Separate iron, antacids, and vitamins for 30 minutes​

  • Encourage increased calcium and vitamin D​

Allopurinol (Aloprim)

• Uses- to treat Gout

• Therapeutic class: uric acid inhibitor​

• MOA:

  • reduces uric acid production​

• Adverse reactions​

  • N/V/D, renal failure, rash ​

• Monitoring: ​

  • ✓ uric acid levels, CBC, LFT’s and renal function ​

• Does not help with acute attacks

Colchicine

• Relieves acute gout attacks + prevents​

• Does not help with pain relief​

• Side effects​

  • Nausea, vomiting, abdominal pain, diarrhea​

  • **bone marrow suppression​

Gout Treatment

• NSAIDS or steroids ​

• Colchicine (Colcrys)-Antigout agent​

  • Begin with symptom onset​

  • Rapid symptom relief, within 12hrs ​

  • Side effects- diarrhea​

• Allopurinol (Zyloprim)-Uric Acid Inhibitor

  • blocks uric acid production​

  • Side effect- rash or Stevens-Johnson syndrome ​

  • bone marrow suppression​