Unit 2 - Growth System

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Last updated 6:05 PM on 9/22/26
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13 Terms

1
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what is the growth system schematic

hypothalamus —> adenohypophysis —> liver/bones —> IGF - I and IGF - II

2
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What is the important hormone for growth?

IGF - I

3
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What does the Type I IGF receptor bind to?

IGF - I with high affinity and IGF - II with low affinity

4
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What does the Type II - IGF receptor bind to?

IGF - II only

5
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Are binding proteins chaperones?

no

6
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What do binding proteins do?

they are molecules that travel to target cells with hormones

7
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Which IGFBP always inhibits growth?

IGFBP - 1

8
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Which IGFBP always facilitates/promotes growth?

IGFBP - 3

9
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What does the protease prostate specific antigen to do IGFBP - 3?

cleaves the binding protein off IGF - I

10
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what happens after IGF - I binds to its receptor?

alpha subunit binds to hormone while the beta subunit, tyrosine kinase, will auto phosphorylate

11
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What does the beta subunit activate?

protein kinase b

12
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What does protein kinase b activate?

MAPK

13
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What does MAPK cause?

cell proliferation (growth)