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Nervous System Overview
Central Nervous System (CNS):
Consists of the brain and spinal cord. Responsible for processing, interpreting, and responding to information.
Peripheral Nervous System (PNS):
Transmits messages to/from CNS. Split into:
Somatic Nervous System (SNS): Controls voluntary movements (e.g., moving limbs).
Autonomic Nervous System (ANS): Controls involuntary functions (e.g., breathing, heart rate).
Sympathetic Branch: “Fight or flight” – increases heart rate, dilates pupils.
Parasympathetic Branch: “Rest and digest” – calms body, slows heart rate.
Structure and Function of Neurons
Types of Neurons:
Sensory Neurons: Carry messages from the senses to the CNS.
Relay Neurons: Connect sensory and motor neurons. Found in the CNS.
Motor Neurons: Carry messages from CNS to muscles/glands.
Neuron Structure:
Dendrites: Receive signals.
Axon: Transmits electrical impulse.
Myelin Sheath: Insulates axon, speeds up transmission.
Nodes of Ranvier: Gaps allowing faster impulse travel.
Axon Terminal: Passes message to next neuron.
Synaptic Transmission
Process:
• electrical impulses (action potentials) reach the presynaptic terminal
• electrical impulses (action potentials) trigger release of neurotransmitters (or named example)
• neurotransmitters cross the synapse from vesicles
• neurotransmitters combine with receptors on the postsynaptic membrane
• stimulation of postsynaptic receptors by neurotransmitters result in either excitation (depolarisation) or inhibition (hyperpolarisation) of the postsynaptic membrane
Excitation vs. Inhibition:
Excitatory neurotransmitters (e.g., adrenaline): increase likelihood of firing.
Inhibitory neurotransmitters (e.g., serotonin): decrease likelihood of firing.
After transmission, the neurotransmitter is either:
Reabsorbed into the presynaptic neuron (reuptake), or
Broken down by enzymes in the synaptic cleft.
Endocrine System and Glands
Endocrine System:
A network of glands that secrete hormones directly into the bloodstream to regulate bodily functions.
Major Glands:
Pituitary Gland: “Master gland” – controls other glands.
Adrenal Gland: Releases adrenaline during stress (fight/flight).
Ovaries/Testes: Produce sex hormones (oestrogen/testosterone).
Fight or Flight Response
Triggered by: Perception of a threat.
Process:
Hypothalamus activates the sympathetic nervous system.
Adrenal medulla releases adrenaline into the bloodstream.
Body prepares for action – heart rate ↑, pupils dilate, digestion stops.
Once threat passes, parasympathetic system returns body to normal.
Localisation of Function in the Brain
Key Areas & Functions:
Motor Cortex (Frontal Lobe): Controls voluntary movements.
Somatosensory Cortex (Parietal Lobe): Processes touch sensations.
Visual Cortex (Occipital Lobe): Processes visual info.
Auditory Cortex (Temporal Lobe): Processes sound.
Broca’s Area (Left Frontal Lobe): Language production.
Wernicke’s Area (Left Temporal Lobe): Language comprehension.
Support:
Broca (Tan): Could understand speech but couldn’t speak → damage to Broca’s Area.
Wernicke (1874): Patients could speak fluently but made no sense → Wernicke’s area damage.
Hemispheric Lateralisation & Split Brain Research
Hemispheric Lateralisation:
Some mental processes are specialised to one hemisphere (e.g., language on the left).
Split-Brain Research – Sperry (1968):
Studied patients who had corpus callosum severed.
Findings:
If a word was shown to left visual field (right hemisphere) → couldn’t verbalise it.
If shown to right visual field (left hemisphere) → could name it.
Conclusion: Language is lateralised to the left hemisphere.
Plasticity & Functional Recovery
Brain Plasticity:
The brain’s ability to change and adapt (e.g., by forming new neural connections).
Functional Recovery:
After brain injury, the brain can “re-wire” itself using secondary neural pathways.
Examples of Functional Recovery:
Axonal Sprouting – new nerve endings form connections.
Reformation of Blood Vessels.
Recruitment of Similar Brain Areas (opposite hemisphere may take over).
Support:
Maguire et al. (2000): London taxi drivers had larger hippocampi → supports brain’s ability to adapt with experience.
Ways of Studying the Brain
Method | Description | Strength | Limitation |
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fMRI | Measures blood flow to brain areas (activity) | Non-invasive, high spatial resolution | Expensive, poor temporal resolution |
EEG | Measures electrical activity via scalp electrodes | Real-time data, good temporal resolution | Can't localise activity |
ERP | Event-related potentials linked to specific stimuli | High temporal resolution | Requires many trials |
Post-Mortem | Analysis of brain after death | Detailed examination of abnormalities | No cause-effect, invasive |
Circadian Rhythms (e.g., Sleep/Wake Cycle)
Definition:
Biological rhythms lasting about 24 hours.
Key Study – Siffre (1975):
Lived in a cave for 6 months with no natural light → his sleep/wake cycle settled to ~25 hours.
Conclusion: Body has an internal clock but is influenced by external cues (e.g., light).
Other Research:
Aschoff & Wever – similar findings in WWII bunker → supports existence of endogenous pacemaker.
Infradian & Ultradian Rhythms
Infradian Rhythms: Last longer than 24 hours (e.g., menstrual cycle).
Study: Stern & McClintock → found menstrual cycles synced via pheromones.
Ultradian Rhythms: Occur more than once in 24 hours (e.g., sleep cycle).
Sleep has 5 stages including REM and deep sleep (90-minute cycles).
Dement & Kleitman: Monitored sleep using EEG – found REM associated with dreaming
Endogenous Pacemakers & Exogenous Zeitgebers
Endogenous Pacemakers:
Internal body clocks (e.g., the suprachiasmatic nucleus (SCN) in the hypothalamus controls circadian rhythms).
Exogenous Zeitgebers:
External cues like light or social routines that reset biological clocks.
Light → SCN → Pineal Gland → Melatonin (sleep hormone).
Research:
DeCoursey et al. (2000): Destroyed SCN in chipmunks → disrupted sleep/wake cycles.
Campbell & Murphy: Light exposure to back of knees shifted circadian rhythms – supports light as a zeitgeber.