PRELIM: Hemoglobin and Iron Kinetics (3)

Blocks ferroportin

What is one major effect of hepcidin on ferroportin?

Decreased intestinal iron absorption

Increased hepcidin activity would be expected to cause:

Blocked ferroportin, decreased absorption, and decreased iron release

Which combination best describes the effects of hepcidin?

Iron release decreases.

If hepcidin blocks ferroportin, what is the overall effect on iron movement into circulation?

Diet → absorption → transferrin → bone marrow → hemoglobin → circulation → macrophages → recycling

Which sequence most accurately represents iron movement from the diet through erythrocyte recycling?

Transferrin

Which protein connects circulating iron transport with delivery to the bone marrow?

Serum iron

Which laboratory test primarily reflects circulating transport iron?

Total Iron-Binding Capacity

What does TIBC stand for?

Transferrin iron-binding capacity

What does TIBC (Total Iron-Binding Capacity) primarily assess?

Transferrin saturation

Which test is associated with the amount of available iron for use?

Bone marrow iron

Which laboratory test is described as the gold standard for assessing iron stores?

Soluble transferrin receptor

Which test is particularly associated with iron deficiency according to the lecture?

Serum iron, ferritin, TIBC, transferrin saturation, and soluble transferrin receptor

Which set contains the major laboratory tests used to evaluate iron status?

100 µg/dL

Which serum iron value falls within the reference range given in the lecture?

350 µg/dL

Which TIBC value falls within the stated reference range?

35%

Which transferrin saturation value is within the stated reference range?

Decreased serum iron, decreased ferritin, increased TIBC, decreased transferrin saturation

Which laboratory pattern is most consistent with iron deficiency?

Iron deficiency

A patient has decreased hemoglobin, decreased serum iron, decreased ferritin, increased TIBC, and decreased transferrin saturation. Which condition is most consistent with these findings?

Increased ferritin, increased serum iron, decreased TIBC, increased saturation

Which laboratory pattern is most consistent with iron overload?

Iron overload

A patient has increased ferritin, increased serum iron, decreased TIBC, and increased transferrin saturation. Which condition is most consistent with these findings?