Schaechters: Chapter 2 Normal Microbiota

Microbiome

________: a complex collection of genomes present in gut with coding capacity for many more metabolic pathways than our own genomes have.

germ fee conditions

Under ________, rodents thrive when given vitamin supplements in diets.

def. Normal microbiota and how can you identify it as benign or pathogenic

________: microorganisms frequently found on or in the body of healthy persons.

* However, no microorganism is intrinsically benign or pathogenic

what parts of the body contain large amounts of Microorganims?

skin; respiratory tract: digetsive tract ; urinary tract ; genital tract

what body parts are usually sterile?

* **blood**
* **cerebrospinal fluid**
* **synovial fluid**
* **deep tissues in general**

location of microorganisms

Depend on ________ (on lumen or in deep tissue) and host ability to maintain homeostasis.

def. Tissue Tropism and by what is it deterinted?

________: reflects the ability of a given pathogen to infect a specific organ or sets of organs.

* determined by __tissue-specific cellular properties,__ like specific receptors on the surface of certain cells, or __physical properties__ like temperature or pH

who do microorganisms fight against to stay in the body?

Microorganisms have to __resist host__ mechanisms and successfully __compete against other microbial species!__

what are the roles of Normla microbiota?

* **A common source of Infection**
* **Immune Stimulation**
* **Keeping out invaders**
* **metabolizing nutrition**

How do we stuy the normal microbiota

* Traditionally raising animals in sterile conditions → **germe-free animals**
* rodents
* chickens

with what characteristics do germ free animals presnet

* under germ fee conditions, rodents thrive when given vitamin supplements in diets
* faster growth

Normal microbiota

microorganisms frequently found on or in the body of healthy persons

Skin

moist areas epically, such as the group and between the toes

Respiratory tract

nose or oropharynx

digestive tract

mouth and large intestine

urinary tract

anterior part of the urethra

Genital system

vagina

Tissue Tropism

reflects the ability of a given pathogen to infect a specific organ or sets of organs

microbiome

a complex collection of genomes present in gut with coding capacity for many more metabolic pathways than our own genomes have