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Central nervous system (CNS)
Includes brain and spinal cord; integrates, processes, and coordinates sensory input and motor output; seat of intelligence, memory, learning, and emotion
Peripheral nervous system (PNS)
All nervous tissue outside CNS; provides sensory information to CNS and carries motor commands from CNS to effectors
Somatic nervous system (SNS)
Efferent division controlling voluntary skeletal muscle contractions
Autonomic nervous system (ANS)
Efferent division controlling involuntary activity of smooth muscle, cardiac muscle, glands, and adipose tissue
Sympathetic division
ANS subdivision (thoracolumbar) most active during stress, exertion, or emergency; “fight or flight”
Parasympathetic division
ANS subdivision (craniosacral) most active at rest; promotes “rest and digest” functions
Neuron
Basic functional unit of nervous system; nerve cell with soma, dendrites, axon, and axon terminals that conducts action potentials
Neuroglia
Supporting cells in CNS and PNS that protect, support, and nourish neurons
Astrocytes
CNS neuroglia that form blood brain barrier, regulate interstitial fluid, and anchor neurons
Oligodendrocytes
CNS neuroglia that form myelin sheaths around CNS axons, creating internodes and nodes
Schwann cells
PNS neuroglia that myelinate segments of peripheral axons or shield groups of unmyelinated axons
Action potential
Rapid, propagated change in membrane potential along the axon that represents a nerve impulse
Chemical synapse
Synapse where neurotransmitter is released from presynaptic vesicles, crosses cleft, and binds receptors on postsynaptic cell
Electrical synapse
Synapse with direct cell
Spinal cord
Cylindrical CNS structure with 31 segments, enlargements, conus medullaris, filum terminale, and cauda equina that conducts information to and from brain
Spinal meninges
Three connective tissue layers (dura mater, arachnoid mater, pia mater) surrounding spinal cord for protection, stability, and shock absorption
Dura mater
Tough, fibrous outer meningeal layer that stabilizes spinal cord and forms epidural space and coccygeal ligament
Arachnoid mater
Middle meningeal layer with subarachnoid space containing cerebrospinal fluid and arachnoid trabeculae
Pia mater
Delicate inner meningeal layer firmly bound to brain and spinal cord surface; contains blood vessels and forms denticulate ligaments
Gray matter
Spinal cord region containing neuron cell bodies and glial cells; organized into posterior, lateral, and anterior horns around central canal
White matter
Spinal cord region containing myelinated and unmyelinated axons organized into posterior, lateral, and anterior columns carrying tracts
Spinal nerve
Mixed peripheral nerve formed by union of dorsal (sensory) and ventral (motor) roots; one pair per spinal segment
Rami communicantes
White (preganglionic) and gray (postganglionic) branches connecting spinal nerve to sympathetic ganglion
Dermatome
A region of skin innervated by sensory fibers of a specific pair of spinal nerves
Nerve plexus
Interwoven network of ventral rami (cervical, brachial, lumbar, sacral) innervating neck, upper limb, pelvic girdle, and lower limb
Cervical plexus
Plexus from ventral rami C1–C4 that innervates neck muscles, diaphragm (phrenic nerve), and skin of head, neck, and chest
Brachial plexus
Plexus from ventral rami C5–T1 that innervates pectoral girdle and upper limb through major nerves such as radial, ulnar, median, and musculocutaneous
Lumbar plexus
Plexus from ventral rami T12–L4 that innervates pelvic girdle and part of lower limb (femoral, obturator, lateral femoral cutaneous, genitofemoral nerves)
Sacral plexus
Plexus from ventral rami L4–S4 that innervates gluteal region, posterior thigh, leg, and foot (sciatic, superior and inferior gluteal, pudendal nerves)
Ascending tract
Sensory pathway carrying information toward the brain (posterior column, spinothalamic, spinocerebellar)
Posterior column tracts
Gracile fasciculus and cuneate fasciculus carrying fine touch, vibration, pressure, and proprioception sensations to cerebral cortex
Spinothalamic tracts
Lateral tract carrying pain and temperature and anterior tract carrying crude touch and pressure to primary sensory cortex
Spinocerebellar tracts
Posterior and anterior tracts carrying proprioceptive information to the cerebellum for coordination
Descending tract
Motor pathway carrying commands from brain to spinal cord and peripheral effectors (corticospinal and subconscious tracts)
Upper motor neuron
CNS neuron whose cell body lies in brainstem or cortex and modulates activity of a lower motor neuron
Lower motor neuron
Motor neuron in brainstem or spinal cord whose axon innervates skeletal muscle fibers
Brain
Major CNS organ including cerebrum, cerebellum, diencephalon, midbrain, pons, and medulla oblongata, responsible for higher functions and vital control
Medulla oblongata
Inferior brainstem region continuous with spinal cord; relays information and contains autonomic nuclei for cardiovascular and respiratory control
Pons
Brainstem bulge superior to medulla with cranial nerve nuclei, respiratory centers, and relay nuclei to cerebellum via cerebellar peduncles
Mesencephalon (midbrain)
Brainstem region with superior and inferior colliculi, red nucleus, and substantia nigra involved in visual and auditory reflexes, muscle tone, and alertness
Diencephalon
Brain region containing thalamus (sensory relay), hypothalamus (autonomic and endocrine control, emotions), and epithalamus (pineal gland)
Cerebellum
Posterior brain region that coordinates complex somatic motor patterns and fine
Cerebrum
Largest brain region with paired hemispheres, gyri, and sulci; responsible for conscious thought, intellectual functions, memory, and voluntary control of skeletal muscles
Ventricular system
Set of four CSF
Cerebrospinal fluid (CSF)
Clear fluid produced by choroid plexus that cushions CNS, supports brain, and transports nutrients and wastes
Choroid plexus
Network of capillaries and specialized ependymal cells in ventricles that produces CSF and helps maintain its composition
Blood brain barrier (BBB)
System of tight endothelial junctions plus astrocyte regulation that restricts movement of substances from blood into CNS interstitial fluid
Sympathetic chain ganglia
Paired ganglia on either side of vertebral column whose postganglionic fibers innervate body wall, limbs, head, neck, and thoracic viscera
Collateral ganglia
Unpaired prevertebral ganglia receiving splanchnic nerves and sending postganglionic fibers to abdominopelvic organs
Adrenal medulla
Inner region of adrenal gland acting as modified sympathetic ganglion that secretes epinephrine and norepinephrine into blood
Visceral reflex
Polysynaptic autonomic reflex arc using preganglionic and postganglionic neurons to produce automatic responses in visceral organs
Long visceral reflex
Visceral reflex in which sensory information travels to CNS and motor output returns via ANS pathways
Short visceral reflex
Visceral reflex in which sensory neurons synapse directly on ganglionic neurons and motor output bypasses CNS
Nicotinic receptor
Type of acetylcholine receptor on all autonomic ganglionic neurons; activation is always excitatory
Muscarinic receptor
Type of acetylcholine receptor on parasympathetic target cells; responses can be excitatory or inhibitory depending on the cell
Dual innervation
Condition in which most visceral organs receive both sympathetic and parasympathetic fibers that often produce opposing (antagonistic) effects