drugs affecting coagulation

warfarin is an ____

anticoagulant

warfarin has a ___ half life

long

warfarin is monitored by _ (2)

PT and INR

for warfarin, PT should be ___ times the control

1.5-2

for warfarin, INR should be ___ times the control

2-3

most common adverse effect of warfarin

bleeding

warfarin has many ___

drug interactions

heparin has a ___ half life

short

heparin requires ____

intensive monitoring

antidote for heparin

protamine sulfate

what value is monitored for heparin

aPTT

adverse effects of heparin (4)

hemorrhage

hematoma

thrombocytopenia

hypersensitivity

what IV med is high alert

heparin

low molecular weight heparin is called

enoxaparin (lovenox)

Pradaxa is a ___ inhibitor

thrombin

Rivaroxaban is a ___ inhibitor

factor Xa

main indication for antiplatelets

prevent arterial thrombosis

3 antiplatelets

aspirin

adenosine diphosphate antagonists

IIb/IIIa receptor antagonists

aspirin persists for ___ days

7-10

daily dose of aspirin

81 mg

adenosine diphosphate antag are ____

prodrugs

clopidogrel (plavix) is an ___

adenosine diphosphate receptor antag

abciximab (reopro) is a ___

glycoprotein IIb/IIIa antagonist

IIb/IIIa antag are only adminstered ___

IV

IIb/IIIa double the risk of ___

major bleeding

thombolytic drugs ar emeant to be used ___

ASAP

major concern of thrombolytics?

bleeding

ending for thrombolytics:

-ase