Pathology Final Exam IP6 - Questions only

Which of the following is most likely to explain this puppy’s lesion?

Blood loss

Reticulocytosis is expected in each of the following patients

• A lab with a heavy burden of Haemonchus contortus

• A dog with immune-mediated hemolytic anemia

• A cat that ingested Tyelenol

Reticulocytosis is NOT expected in which patient

A foal with neonatal isoerythrolysis

Tissue from a dog. Which of is the most likely explanation?

Hemolysis

Tissue from a cow. The mucous membranes are a dull brown. What is the xplanation?

Methemoglobinemia

Which of the following is likely associated with erythroid hyperplasia of the bone marrow?

Immune-mediated hemolytic anemia

Which is the best location for a bone marrow biopsy?

B

Lymph node from a pig. Name two foreign animal diseases you should rule out

1. African swine fever

2. Classical swine fever

In cats, which of the following types of lymphoma is associated with feline leukemia virus (FeLV)

Alimentary

Which of the following is most likely to cause diffuse “meaty” splenomegatly

• acute septicemia

• hemangiosarcoma

• histoplasmosis

• splenic vovulus

histoplasmosis

Which of the following conditions is most likely to be associated with a very small thymus?

Infection with feline panleukopenia virus

Which of the following statements about bovine enzootic lymphoma is False?

• Bovine leukosis virus (BLV) primarily infects B cells

• BLV-associated lymphoma usually affects cattle over 2 years old.

• Involvement of the spinal cord is extremely rare

• About 30% of BLV-infected cattle will develop a persistent lymphocytosis

Involvement of the spinal cord is extremely rare = HAUKS!!

What is the most likely cause of the lesion in this photograph?

Corynebacterium pseudotuberculosis

Which of the following situations does NOT indicate a bone marrow biopsy for thorough assessment of the patient?

• Persistent neutropenia

• Multifocal osteolysis in a dog with hyperglobinemia

• Multicentric lymphoma that is being staged in order to make a treatment plan

• Hemolytic anemia with a positive slide agglutination test

hemolytic anemia with a positive slide agglutination test

Which of the following is MOST LIKELY to cause a diffuse “meaty” enlargement of the spleen?

• acute septicemia

• hemangiosarcoma

• histoplasmosis

• volvulus

histoplasmosis

Case: A 12 yo beagle presents with lethargy, decreased appetite, and evidence of back pain. Labwork reveals markedly elevated immunoglobulins in the blood. Imaging reveals multifocal lytic lesions in the skeleton. Based on these clues, which of the following do you expect to find in a bone marrow aspirate?

excessive numbers of plasma cells

Which of the following would NOT be expected to cause pancytopenia?

• consumption of bracken fern

• recent exposure to ionizing radiation

• acute infection with canine parvovirus

• severe iron deficiency

severe iron deficiency

A distressed client lost 8 cattle in the last 24 hours. they were turned out onto draught-stressed pasture. on necropsy, the blood appears muddy brown. what is the most likely explanation?

oxidation of iron by nitrates

Most likely explanation for the gross appearance of this dog’s bone marrow?

this dog’s anemia was due to hemolysis or blood loss

Two day old thoroughbred foal. This lesion is most likely the result of:

maternal antibodies directed against RBCs

During necropsy of a calf you notice these structures along the aorta and within the retroperitoneal fat. Conclusion?

normal

Which of the following clinical findings is most specific for intravascular hemolysis?

hemouria = picture B

Which diagnosis is most consistent with the gross lesion?

acute infarcts

Endoscopic view of a horse’s guttural pouch. Likely cause?

Streptococcus equi subsp. equi

Which of the following is the most likely explanation for the photograph?

Zinc-induced hemolysis

Crusty old cats:

• An aged cat is presented for a wellness check

• The cat has moderate to severe dental disease and his submandibular lymph nodes are moderately enlarged.

• The rest of his physical exam and bloodwork are unremarkable

• Given these clinical findings, what would you most expect to find on cytology of the enlarged lymph nodes?

predominantly small lymphocytes with moderately increased medium/large lymphocytes and plasma cells

An outdoor cat is brought to your emergency clinic with rapid onset of severe lethargy, fever, and icterus. The cat cannot be saved. Postmortem examination at the local diagnostic lab reveals organism-laden macrophages within most blood vessels (see image). Which organism is responsible?

Cytauxzoon felis

Which of the following statements about Histoplasma capsulatum is TRUE?

this organism may cause myelophthisis once it is widely disseminated

An aged cat is presented for his annual wellness check. The cat has moderate to severe dental disease. His submandibular lymph nodes are midly and symmetrical enlarged and non-painful. His physical exam and bloodwork are otherwise unremarkable. Given these clinical findings, what would you most expect to find if you performed a fine needle aspirate of the enlarged lymph nodes?

Predominantly small lymphocytes with mildly increased medium to large lymphocytes and plasma cells

Postmortem examination of a 3 month old foal reveals pyogranulomatous pneumonia AND pyogranulomatous lymphadenitis of the mesenteric lymph nodes. Which of the following agents is most likely responsible?

Rhodococcus equi

This photograph shows a longitudinal section of the mid-shaft femur from an adult dog that has a two-month history of anemia before its death. ITs white blood cell numbers and morphology were all within normal limits. Which of the following is the most likely explanation for the gross appearance of this dog’s bone marrow?

This dog’s anemia was due to hemolysis or blood loss

Nodular hyperplasia of the liver in dogs:

is a benign lesion

CAuses of centrolobular hepatic necorsis

• Aflatoxin

• Anemia

• Heart failure

Acute pancreatitis in dogs results in:

• necrosis of pancreas and surrounding adipose tissue

• Hemorrhage

• Inflammation

Metabolic alterations related to severe liver dysfunction:

• Result in clinical signs of central nervous system disease

• Are not usually detected until the majority of the functional mass of the liver is lost.

• Result in clotting abnormalities

Random multifocal hepatic necrosis would be expected as a result of:

• Equine herpesvirus type 1 infection of an equine fetus

• Francisella tularensis infection in a rabbit

• Canine herpesvirus infection in a puppy.

Name the most common cause of hypercalcemia in dogs

Lymphoma

This photo shows the mandibular lymph node of a pig. Name two foreign animal diseases that should be on your differential list.

1. classical swine fever

2. African swine fever

You perform a necropsy of a recently weaned piglet in thin body condition and notice that multiple lymph nodes are enlarged. Which virus is your top differential

Porcine circovirus 2

Name the organism (genus) shown in the photograph.

Mycobacteria

You receive the results of a complete blood count with the following comment: “Marked neutrophilia with a left shift”. in this scenario, the term “left shift” refers to increased numbers of which cells?

Band neutrophils

Random multifocal hepatic necrosis would be expected as a result of

• equine herpes virus type 1 infection of an equine fetus

• portosystemic shunt in a dog

• torsion of a liver lobe in a dog

equine herpes virus type 1 infection of an equine fetus

Causes of centrolobular hepatic necrosis

• Aflatoxin

• Anemia

• Heart failure

An accentuated lobular pattern in the liver

• is a result of hepaticlipidosis

• Is a result of centrilobular necrosis

Nodular hyperplasia of the liver in dogs

is a benign lesion