2: Drug Class

ASA / Aspirin

Nonselective NSAID; salicylate; antiplatelet

Ibuprofen (Advil, Motrin)

Mixed COX-1/COX-2 NSAID; phenylpropionic acid derivative

Naproxen (Aleve, Anaprox, Naprosyn)

Mixed COX-1/COX-2 NSAID; phenylpropionic acid derivative

Diclofenac (Voltaren)

Mixed COX-1/COX-2 NSAID; pyrroleacetic acid derivative

Diclofenac + Misoprostol (Arthrotec)

NSAID + prostaglandin E1 analog

Flurbiprofen

NSAID

Ketoprofen

NSAID

Ketorolac

Potent NSAID

Etodolac

NSAID

Celecoxib (Celebrex)

Selective COX-2 inhibitor

Rofecoxib (Vioxx)

Selective COX-2 inhibitor (withdrawn)

Acetaminophen / Paracetamol (Tylenol)

Non-opioid analgesic/antipyretic

N-acetylcysteine (Mucomyst)

Acetaminophen antidote; glutathione precursor

Misoprostol (Cytotec)

Prostaglandin E1 analog

Mifepristone

Progesterone receptor antagonist

Ergonovine

Ergot alkaloid uterotonic

Alprostadil

Prostaglandin E1 analog

Morphine

Full opioid agonist

Codeine

Weak opioid agonist; prodrug

Acetaminophen + Codeine (Tylenol #1-#4)

Non-opioid analgesic + opioid agonist combination

Methadone

Full mu-opioid agonist

Heroin (Diacetylmorphine)

Opioid agonist

Fentanyl (Sublimaze)

Potent full opioid agonist

Oxycodone (OxyNEO, OxyContin)

Full opioid agonist

Oxycodone + Acetaminophen (Percocet)

Opioid + non-opioid analgesic combination

Oxycodone + Aspirin (Percodan)

Opioid + NSAID/antiplatelet combination

Tramadol

Weak opioid agonist; monoamine reuptake inhibitor

Tramadol + Acetaminophen (Tramacet)

Opioid-like analgesic + acetaminophen

Naloxone (Narcan)

Opioid antagonist

Naltrexone (Trexan)

Long-acting opioid antagonist

Buprenorphine (BuTrans, Buprenex)

Partial mu-opioid agonist; high-affinity opioid

Epinephrine

Adrenergic agonist

Diphenhydramine (Benadryl)

First-generation H1 antihistamine; ethanolamine

Tripelennamine

First-generation H1 antihistamine; ethylenediamine

Chlorpheniramine (Chlor-Trimeton)

First-generation H1 antihistamine; alkylamine

Promethazine (Phenergan)

First-generation H1 antihistamine; phenothiazine

Hydroxyzine (Vistaril)

First-generation H1 antihistamine; piperazine

Cyclizine (Antivert)

First-generation H1 antihistamine; piperazine

Meclizine

First-generation H1 antihistamine

Doxylamine + Pyridoxine (Bendectin/Diclectin-like)

First-generation H1 antihistamine + vitamin B6

Cetirizine (Zyrtec)

Second-generation H1 antihistamine

Fexofenadine (Allegra)

Second-generation H1 antihistamine

Loratadine (Claritin)

Second-generation H1 antihistamine

Desloratadine (Clarinex)

Second-generation H1 antihistamine

Azelastine

Second-generation H1 antihistamine; intranasal

Terfenadine (Seldane)

Second-generation H1 antihistamine (withdrawn)

Cimetidine (Tagamet)

H2 receptor antagonist

Ranitidine (Zantac)

H2 receptor antagonist

Famotidine (Pepcid)

H2 receptor antagonist

Nizatidine (Axid)

H2 receptor antagonist

Penicillin G

Natural penicillin; beta-lactam

Penicillin V

Natural penicillin; beta-lactam

Amoxicillin

Aminopenicillin beta-lactam

Ampicillin

Aminopenicillin beta-lactam

Cloxacillin

Antistaphylococcal penicillin

Piperacillin + Tazobactam

Extended-spectrum penicillin + beta-lactamase inhibitor

Clavulanic acid

Beta-lactamase inhibitor

Tazobactam

Beta-lactamase inhibitor

Cefazolin

First-generation cephalosporin

Cephalothin

First-generation cephalosporin

Cephalexin

First-generation oral cephalosporin

Cefoxitin

Second-generation cephalosporin/cephamycin

Cefaclor

Second-generation cephalosporin

Cefuroxime

Second-generation cephalosporin

Cefotaxime

Third-generation cephalosporin

Ceftriaxone

Third-generation cephalosporin

Ceftazidime

Third-generation antipseudomonal cephalosporin

Ceftolozane + Tazobactam

Antipseudomonal cephalosporin + beta-lactamase inhibitor

Cefixime

Third-generation oral cephalosporin

Cefepime

Fourth-generation cephalosporin

Ceftobiprole

Fifth-generation cephalosporin

Imipenem + Cilastatin

Carbapenem + dehydropeptidase inhibitor

Meropenem

Carbapenem

Ertapenem

Carbapenem

Vancomycin

Glycopeptide cell-wall inhibitor

Daptomycin

Lipopeptide antibacterial

Streptomycin

Aminoglycoside

Neomycin

Aminoglycoside

Kanamycin

Aminoglycoside

Tobramycin

Aminoglycoside

Gentamicin

Aminoglycoside

Amikacin

Aminoglycoside

Netilmicin

Aminoglycoside

Ciprofloxacin

Fluoroquinolone

Levofloxacin

Fluoroquinolone

Moxifloxacin

Fluoroquinolone

Metronidazole

Nitroimidazole

Erythromycin

Macrolide

Clarithromycin

Macrolide

Azithromycin

Macrolide

Clindamycin

Lincosamide

Sulfamethoxazole + Trimethoprim (TMP/SMX)

Antifolate combination

Sulfonamides

Antifolate antibacterial

Trimethoprim

Antifolate antibacterial

Tetracycline

Tetracycline antibiotic

Tigecycline

Glycylcycline tetracycline derivative

Amphotericin B

Polyene antifungal

Liposomal Amphotericin B (Ambisome)

Polyene formulation

Amphotericin B deoxycholate (Fungizone)

Polyene formulation

Nystatin

Polyene antifungal