NEUROTRANSMITTER/ANTISPASTICITY/ANXIOLYTICS

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Last updated 4:16 AM on 6/29/26
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27 Terms

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inhibitory or excitatory: ACETYLCHOLINE

excitatory

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inhibitory or excitatory: DOPAMINE

mixed (inhibitory/excitatory)

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inhibitory or excitatory: NOREPINEPHRINE

excitatory

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inhibitory or excitatory: SEROTONIN

inhibitory

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inhibitory or excitatory: GABA

inhibitory

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inhibitory or excitatory: GLYCINE

inhibitory

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inhibitory or excitatory: GLUTAMATE

excitatory

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inhibitory or excitatory: ASPARTATE

excitatory

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inhibitory or excitatory: SUBSTANCE P

excitatory

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inhibitory or excitatory: ENKEPHALINS

inhibitory

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indications baclofen

MS, CP, SCI

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tizanidine indications

sci spasticity

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clonidine indications

hypertension, adhd

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clonazepam indications

myoclonic, absence seizures, panic disorder

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dantrolenea indications

tbi, cp, stroke, malignant hyperthermia

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diazepam indications

muscle spasm, spasticity, anxiety, status epelipticus

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botulinum toxin indications

chronic migraine, focal spasticity, cosmetics

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benzodiapines (anxiolytics) moa

increases frequency of Cl channel opening, induces hyperpolarization

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non benzodiazepines (anxiolytics) moa

buspirones: partial agonist 5HT1a, Z drugs: selectively bind to a1 subunit of GABA A receptor

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barbiturates (anxiolytics)

binds to GABA A, prolongs Cl channel opening

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MOA baclofen

  1. GABA B receptor agonist

  2. inhibits mono/polysynaptic reflexes

  3. blocks release of excitatory neurotransmitter

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MOA tizanidine

  1. a2 adrenergic receptor agonist

  2. stimulated in brainstem

  3. blocks release of excitatory neurotransmitter

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clonidine MOA

  1. a2 adrenergic receptor agonist

  2. acts centrally

  3. reduces CNS output/flow

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clonazepam MOA

  1. activates GABA receptor

  2. increases chloride ions in post synaptic cell

  3. reduces action potentials = reduces mono/polysynaptic reflexes

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dantrolenea MOA

  1. inhibits Ca2+ release from SR

  2. blocks ryanodine receptors

  3. inhibits muscle contraction

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botulinum toxin

  1. prevents ACh release from presynaptic membrane

  2. muscle contractions decrease/calmer

  3. cleavage of SNARE protein complex (SNAP 25)

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diazepam MOA

  1. enhances GABA A for (inhibitory effects of) GABA

  2. increased Cl- flow